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IPR006166 is a ERCC4 domain.
<p>This entry represents a structural domain found in several DNA repair nucleases, such as Rad1, XPF and crossover junction endonucleases EME1 and Mus81 [[cite:PUB00026231], [cite:PUB00044977]]. The XPF/Rad1/Mus81-dependent nuclease family specifically cleaves branched structures generated during DNA repair, replication, and recombination, and is essential for maintaining genome stability. The nuclease domain architecture exhibits remarkable similarity to those of restriction endonucleases.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). | ||
| Molecular function | Nuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: DNA repair endonuclease UVH1-like [Glycine max] gi|356541275|ref|XP_003539104.1| | 12 | ||
| – | DNA repair endonuclease UVH1 [Medicago truncatula] gi|357482211|ref|XP_003611391.1| | 12 | ||
| – | PREDICTED: crossover junction endonuclease MUS81-like [Cicer arietinum] gi|502165003|ref|XP_004513369.1| | 11 | ||
| – | PREDICTED: crossover junction endonuclease EME1B-like isoform X1 [Cicer arietinum] gi|502139959|ref|XP_004503990.1| | 6 | ||
| – | DNA repair endonuclease UVH1-like protein; TAIR: AT5G41150.1 Restriction endonuclease, type II-like superfamily protein; Swiss-Prot: sp|Q9LKI5|XPF_ARATH DNA repair endonuclease UVH1; TrEMBL-Plants: tr|K7LMX6|K7LMX6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0418900 | 12 | ||
| – | Crossover junction endonuclease MUS81-like protein; TAIR: AT4G30870.1 Restriction endonuclease, type II-like superfamily protein; Swiss-Prot: sp|Q5W9E7|MUS81_ARATH Crossover junction endonuclease MUS81; TrEMBL-Plants: tr|G7J1L2|G7J1L2_MEDTR Crossover junction endonuclease MUS81-like protein; Found in the gene: LotjaGi3g1v0115900 | 10 | ||
| – | Crossover junction endonuclease EME1; TAIR: AT2G22140.1 essential meiotic endonuclease 1B; Swiss-Prot: sp|C5H8J1|EME1B_ARATH Crossover junction endonuclease EME1B; TrEMBL-Plants: tr|G7LC63|G7LC63_MEDTR Crossover junction endonuclease EME1; Found in the gene: LotjaGi4g1v0405500 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 14.29 |