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IPR033382 is a Ubiquitin-specific peptidase 24, UBA domain.
<p>Ubiquitin-specific peptidase 24 (USP24, MEROPS identifier C19.047) is a de-ubiquitinating enzyme that is associated with late-onset Parkinson's Disease [[cite:PUB00078668]]. The enzyme is known to remove ubiquitin from damage-specific DNA-binding protein 2 (DDB2), increasing its stability. DDB2 is involved in DNA damage recognition in the nucleotide excision repair pathway, and is a component of an E3 ligase that targets XPC, histones and DDB2 itself [[cite:PUB00078669]]. USP24 also de-ubiquitinates p53, and cells are resistant to apoptosis following UV irradiation if USP24 is depleted because p53 is stabilized [[cite:PUB00078670]]. Single-nucleotide polymorphisms of the USP24 gene have been identified in lung cancer malignancy and could be diagnostic markers for the disease [[cite:PUB00078671]]. The USP24 gene is up-regulated when the USP9X gene is down-regulated by shRNA, leading to increased survival of B-cell myeloma cells [[cite:PUB00078672]]. USP24 positively regulates ferritinophagy, a process in which ferritin is degraded in lysosomes and releases free iron [[cite:PUB00095288]].</p> <p>This entry represents the N-terminal ubiquitin-associated (UBA) domain of UBP24.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Protein deubiquitination | The removal of one or more ubiquitin groups from a protein. | ||
| Molecular function | Thiol-dependent ubiquitinyl hydrolase activity | Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: ubiquitin carboxyl-terminal hydrolase 24-like [Cicer arietinum] gi|502146222|ref|XP_004506356.1| | 11 | ||
| – | PREDICTED: ubiquitin carboxyl-terminal hydrolase 24-like [Fragaria vesca subsp]. vesca] gi|470134479|ref|XP_004303077.1| | 4 | ||
| – | PREDICTED: ubiquitin carboxyl-terminal hydrolase 24-like [Glycine max] gi|356531617|ref|XP_003534373.1| | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF54001 | SUPERFAMILY | 1 | 33.33 |