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IPR033562 is a Patatin-like phospholipase domain-containing protein.
<p>This entry includes patatin-like phospholipase domain-containing proteins 1-5 (PNPLA1-5) from humans and Atgl-1 from Caenorhabditis elegans. They are a group of lipid hydrolases.</p> <p>Atgl-1 may play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion [[cite:PUB00079086], [cite:PUB00079087], [cite:PUB00079088], [cite:PUB00079089], [cite:PUB00079090], [cite:PUB00079091]].</p> <p>In humans PNPLA1 has a role in the formation of the epidermal lipid barrier; mutations in this gene are associated with the skin disorder known as ichthyosis [[cite:PUB00079092]]. PNPLA1 acts as an omega-hydroxyceramide transacylase involved in the synthesis of omega-O-acylceramides (esterified omega-hydroxyacyl-sphingosine; EOS), which are extremely hydrophobic lipids involved in skin barrier formation [[cite:PUB00096628], [cite:PUB00089051]]. It catalyzes the last step of the synthesis of omega-O-acylceramides by transferring linoleic acid from triglycerides to an omega-hydroxyceramid [[cite:PUB00089051]].</p> <p>Human PNPLA2 catalyses the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets [[cite:PUB00079093]]. PNPLA3 has both triacylglycerol lipase and acylglycerol O-acyltransferase activities [[cite:PUB00079094]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Lipid catabolic process | The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. | ||
| Molecular function | Hydrolase activity | Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Patatin; TAIR: AT1G33270.1 Acyl transferase/acyl hydrolase/lysophospholipase superfamily protein; Swiss-Prot: sp|Q8BJ56|PLPL2_MOUSE Patatin-like phospholipase domain-containing protein 2; TrEMBL-Plants: tr|A0A0L9VG75|A0A0L9VG75_PHAAN Patatin; Found in the gene: LotjaGi6g1v0358500 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 100.00 |