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IPR033661

Source: InterPro

Description

IPR033661 is a Phosphatidylserine decarboxylase, eukaryotic type 1.

<p>A non-mitochondrial type I phosphatidylserine decarboxylase has been identified in Plasmodium falciparum [[cite:PUB00079956]].</p> <p>This entry represents the eukaryotic type 1 subfamily.</p> <p>Phosphatidylserine decarboxylase plays a pivotal role in the synthesis of phospholipid by the mitochondria. The substrate phosphatidylserine is synthesized extramitochondrially and must be translocated to the mitochondria prior to decarboxylation [[cite:PUB00008264]]. Phosphatidylserine decarboxylases [ec:4.1.1.65] is responsible for conversion of phosphatidylserine to phosphatidylethanolamine and plays a central role in the biosynthesis of aminophospholipids [[cite:PUB00008265]].</p> <p>Phosphatidylserine decarboxylases (PSDs) have been classified in two types. Type I PSDs include enzymes of eukaryotic mitochondria and bacterial origin which contain the amino acid sequence LGST as a characteristic motif. Type II PSDs are found in the endomembrane system of eukaryotes and contain a typical GGST motif. These characteristic motifs are considered as autocatalytic cleavage sites where proenzymes are split into alpha and beta subunits [[cite:PUB00078006]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004609
Molecular function Phosphatidylserine decarboxylase activity Catalysis of the reaction: H(+) + phosphatidyl-L-serine = CO(2) + phosphatidylethanolamine.
Subterm of
GO:0005739
Cellular component Mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj2g3v2001390.1
– PREDICTED: phosphatidylserine decarboxylase proenzyme-like isoform X3 [Cicer arietinum] gi|502160315|ref|XP_004511705.1|
Domains
11
LotjaGi2g1v0421700.1
– Phosphatidylserine decarboxylase proenzyme; TAIR: AT4G16700.1 phosphatidylserine decarboxylase 1; Swiss-Prot: sp|Q84V22|PSD1_ARATH Phosphatidylserine decarboxylase proenzyme 1, mitochondrial; TrEMBL-Plants: tr|A0A0S3T6A6|A0A0S3T6A6_PHAAN Phosphatidylserine decarboxylase proenzyme 1, mitochondrial; Found in the gene: LotjaGi2g1v0421700
Domains
11

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TRANSMEMBRANE Phobius 1 50.00