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IPR033841 is a Ubiquitin-specific peptidase 48.
<p>Ubiquitin carboxyl-terminal hydrolases (UCH) ([ec:3.1.2.12]) [[cite:PUB00000623]] are thiol proteases that recognise and hydrolyse the peptide bond at the C-terminal glycine of ubiquitin. These enzymes are involved in the processing of poly-ubiquitin precursors as well as that of ubiquinated proteins. The deubiquitinsing proteases can be split into 2 size ranges, 20-30kDa ([interpro:IPR001578]) and 100-200kDa [[cite:PUB00003577]]: the second class consist of large proteins (800 to 2000 residues) that belong to the peptidase family C19, and this group is currently represented by yeast UBP1 [[cite:PUB00069572]].</p> <p>This entry contains the peptidase domain for ubiquitin-specific peptidase 48 (USP48; MEROPS identifier C19.068). In animals, USP48 is found in the nucleus where it trims long Lys48-linked free and substrate-anchored ubiquitin-chains, rather than completely disassembling them; a catalytic property only shared with ataxin-3 and otubain-1. USP48 ubiquitin-chain-trimming activity is regulated by casein-kinase-2-mediated phosphorylation in response to cytokine-stimulation. USP48 controls the turnover of activated NF-kB/RelA in the nucleus together with the CSN and contributes to a timely control of immune responses [[cite:PUB00081375]].</p> <p>In plants, the gene name is USP26, which should not be confused with USP26 from mammals. USP26 deubiquitinates histone H2B and is required for heterochromatin silencing [[cite:PUB00081376]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Thiol-dependent ubiquitin-specific protease activity | Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Ubiquitin carboxyl-terminal hydrolase; TAIR: AT3G49600.1 ubiquitin-specific protease 26; Swiss-Prot: sp|Q9SCJ9|UBP26_ARATH Ubiquitin carboxyl-terminal hydrolase 26; TrEMBL-Plants: tr|I1M9Q7|I1M9Q7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0064500 | 24 | ||
| – | Ubiquitin carboxyl-terminal hydrolase; TAIR: AT3G49600.1 ubiquitin-specific protease 26; Swiss-Prot: sp|Q9SCJ9|UBP26_ARATH Ubiquitin carboxyl-terminal hydrolase 26; TrEMBL-Plants: tr|I1M9Q7|I1M9Q7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0064500 | 24 | ||
| – | Ubiquitin carboxyl-terminal hydrolase; TAIR: AT3G49600.1 ubiquitin-specific protease 26; Swiss-Prot: sp|Q9SCJ9|UBP26_ARATH Ubiquitin carboxyl-terminal hydrolase 26; TrEMBL-Plants: tr|I1M9Q7|I1M9Q7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0064500 | 24 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 33.33 |