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IPR033851 is a Mitochondrial intermediate peptidase.
<p>Mitochondrial intermediate peptidase (MIP; MEROPS identifier M03.006; [ec:3.4.24.59]) belongs to the widespread peptidase subfamily M3A [[cite:PUB00003579]]. MIP shows similarity to the thimet oligopeptidase (TOP). These proteins are enriched in cysteine residues, two of which are highly conserved, suggesting their importance to stability as well as in formation of metal binding sites, thus playing a role in MIP activity [[cite:PUB00081423]].</p> <p>MIP is one of three peptidases responsible for the proteolytic processing of both nuclear and mitochondrial encoded precursor polypeptides targeted to the various subcompartments of the mitochondria [[cite:PUB00081423], [cite:PUB00081426]]. It cleaves intermediate-size proteins initially processed by mitochondrial processing peptidase (MPP) to yield a processing intermediate with a typical N-terminal octapeptide that is sequentially cleaved by MIP to mature-size protein [[cite:PUB00081422]]. MIP cleaves precursor proteins of respiratory components, including subunits of the electron transport chain and tri-carboxylic acid cycle enzymes, and components of the mitochondrial genetic machinery, including ribosomal proteins, translation factors, and proteins required for mitochondrial DNA metabolism. It has been suggested that the human MIP (HMIP polypeptide; gene symbol MIPEP) may be one of the loci predicted to influence the clinical manifestations of Friedreich's ataxia (FRDA), an autosomal recessive neurodegenerative disease caused by lack of human frataxin [[cite:PUB00081425]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Metalloendopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. | ||
| Cellular component | Mitochondrial matrix | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. | ||
| Biological process | Protein processing involved in protein targeting to mitochondrion | The cleavage of peptide bonds in proteins, usually near the N terminus, contributing to the process of import into the mitochondrion. Several different peptidases mediate cleavage of proteins destined for different mitochondrial compartments. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: mitochondrial intermediate peptidase-like isoform X2 [Cicer arietinum] gi|502127359|ref|XP_004499673.1| | 10 | ||
| – | PREDICTED: mitochondrial intermediate peptidase-like isoform X1 [Cicer arietinum] gi|502127357|ref|XP_004499672.1| | 14 | ||
| – | Mitochondrial intermediate peptidase; TAIR: AT5G51540.1 Zincin-like metalloproteases family protein; Swiss-Prot: sp|F4KDA5|MIPEP_ARATH Probable mitochondrial intermediate peptidase, mitochondrial; TrEMBL-Plants: tr|A0A0R0KE54|A0A0R0KE54_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0329900 | 11 | ||
| – | Mitochondrial intermediate peptidase; TAIR: AT5G51540.1 Zincin-like metalloproteases family protein; Swiss-Prot: sp|F4KDA5|MIPEP_ARATH Probable mitochondrial intermediate peptidase, mitochondrial; TrEMBL-Plants: tr|K7KJJ4|K7KJJ4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0329900 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd06457 | CDD | 1 | 25.00 |