Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message

GO:0006627

View this GO term in other databases

Overview

Field Value
Namespace Biological process
Short description Protein processing involved in protein targeting to mitochondrion
Full defintion The cleavage of peptide bonds in proteins, usually near the N terminus, contributing to the process of import into the mitochondrion. Several different peptidases mediate cleavage of proteins destined for different mitochondrial compartments.
Subterm of

Relationships

The relationship of GO:0006627 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

A force layout showing the ancestor tree for GO:0006627, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.

  • Drag and drop nodes to manually position (i.e. fix) them
  • Double click on a node to unfix the node
  • Press Alt and double click to visit the page containing further details of a GO term
  • Right clicking on a node will reveal a context menu

Controls

Force layout

Every force layout is different—we have picked a set of parameters which suits most GO ancestor tree chart well. If you mess something up—don't worry: hitting the "reset view" button above will reset the chart to its default layout.

Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
GOCmcc
PMID
Mitochondrial processing peptidases.Gakh O, Cavadini P, Isaya G
Biochim Biophys Acta. 2002 Sep 2; 1592 (1): 63–77.PMID: 12191769

Three peptidases are responsible for the proteolytic processing of both nuclearly and mitochondrially encoded precursor polypeptides targeted to the various subcompartments of the mitochondria. Mitochondrial processing peptidase (MPP) cleaves the vast majority of mitochondrial proteins, while inner membrane peptidase (IMP) and mitochondrial intermediate peptidase (MIP) process specific subsets of precursor polypeptides. All three enzymes are structurally and functionally conserved across species, and their human homologues begin to be recognized as potential players in mitochondrial disease.

Associated Lotus transcripts 7

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj0g3v0319349.1
– PREDICTED: mitochondrial intermediate peptidase-like isoform X2 [Cicer arietinum] gi|502127359|ref|XP_004499673.1|
GO terms
3
Lj0g3v0319349.2
– PREDICTED: mitochondrial intermediate peptidase-like isoform X1 [Cicer arietinum] gi|502127357|ref|XP_004499672.1|
GO terms
3
LotjaGi1g1v0440100.2
– Mitochondrial inner membrane protease subunit 2; TAIR: AT3G08980.1 Peptidase S24/S26A/S26B/S26C family protein; Swiss-Prot: sp|Q6AZD4|IMP2L_DANRE Mitochondrial inner membrane protease subunit 2; TrEMBL-Plants: tr|I3SVG3|I3SVG3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0440100
GO terms
4
LotjaGi3g1v0329900.1
– Mitochondrial intermediate peptidase; TAIR: AT5G51540.1 Zincin-like metalloproteases family protein; Swiss-Prot: sp|F4KDA5|MIPEP_ARATH Probable mitochondrial intermediate peptidase, mitochondrial; TrEMBL-Plants: tr|A0A0R0KE54|A0A0R0KE54_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0329900
GO terms
3
LotjaGi3g1v0329900.2
– Mitochondrial intermediate peptidase; TAIR: AT5G51540.1 Zincin-like metalloproteases family protein; Swiss-Prot: sp|F4KDA5|MIPEP_ARATH Probable mitochondrial intermediate peptidase, mitochondrial; TrEMBL-Plants: tr|K7KJJ4|K7KJJ4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0329900
GO terms
3
LotjaGi3g1v0372500.1
– Mitochondrial-processing peptidase subunit alpha; TAIR: AT1G51980.1 Insulinase (Peptidase family M16) protein; Swiss-Prot: sp|P29677|MPPA_SOLTU Mitochondrial-processing peptidase subunit alpha; TrEMBL-Plants: tr|I1KGH6|I1KGH6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0372500
GO terms
1
LotjaGi4g1v0443400.1
– Mitochondrial-processing peptidase subunit alpha; TAIR: AT1G51980.1 Insulinase (Peptidase family M16) protein; Swiss-Prot: sp|P29677|MPPA_SOLTU Mitochondrial-processing peptidase subunit alpha; TrEMBL-Plants: tr|G7L7C9|G7L7C9_MEDTR Processing peptidase; Found in the gene: LotjaGi4g1v0443400
GO terms
1

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0006627
Biological process Protein processing involved in protein targeting to mitochondrion 1 14.29