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IPR033944 is a Cytochrome c oxidase subunit I domain.
<p>Cytochrome c oxidase ([ec:7.1.1.9]) is a key enzyme in aerobic metabolism. Proton pumping haem-copper oxidases represent the terminal, energy-transfer enzymes of respiratory chains in prokaryotes and eukaryotes. The CuB-haem a3 (or haem o) binuclear centre, associated with the largest subunit I of cytochrome c and ubiquinol oxidases ([ec:1.10.3.11]), is directly involved in the coupling between dioxygen reduction and proton pumping [[cite:PUB00002253], [cite:PUB00006485]]. Some terminal oxidases generate a transmembrane proton gradient across the plasma membrane (prokaryotes) or the mitochondrial inner membrane (eukaryotes).</p> <p>The enzyme complex consists of 3-4 subunits (prokaryotes) up to 13 polypeptides (mammals) of which only the catalytic subunit (equivalent to mammalian subunit I (CO I) is found in all haem-copper respiratory oxidases. The presence of a bimetallic centre (formed by a high-spin haem and copper B) as well as a low-spin haem, both ligated to six conserved histidine residues near the outer side of four transmembrane spans within CO I is common to all family members [[cite:PUB00001256], [cite:PUB00000581], [cite:PUB00001153]]. In contrast to eukaryotes the respiratory chain of prokaryotes is branched to multiple terminal oxidases. The enzyme complexes vary in haem and copper composition, substrate type and substrate affinity. The different respiratory oxidases allow the cells to customize their respiratory systems according to a variety of environmental growth conditions [[cite:PUB00002253]].</p> <p>This entry represents a domain found in cytochrome c oxidase subunit I.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Respiratory chain complex IV | A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Cytochrome c oxidase subunit [Medicago truncatula] gi|357436121|ref|XP_003588336.1| | 20 | ||
| – | Cytochrome c oxidase subunit [Medicago truncatula] gi|357436121|ref|XP_003588336.1| | 20 | ||
| – | Cytochrome c oxidase subunit [Medicago truncatula] gi|357436121|ref|XP_003588336.1| | 15 | ||
| – | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01663 | CDD | 1 | 25.00 |