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IPR034143 is a snRNP70, RNA recognition motif.
<p>This entry represents the RNA recognition motif (RRM) of snRNP70 (also known as U1-70K), a key component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome [[cite:PUB00082760]].</p> <p>U1-70K plays an essential role in targeting the U1 snRNP to the 5' splice site through protein-protein interactions with regulatory RNA-binding splicing factors, such as the RS protein ASF/SF2. It can also specifically bind to stem-loop I of the U1 small nuclear RNA (U1 snRNA) contained in the U1 snRNP complex. It also mediates the binding of U1C, another U1-specific protein, to the U1 snRNP complex [[cite:PUB00051148]].</p> <p>U1-70K contains a conserved RNA recognition motif (RRM), followed by an adjacent glycine-rich region at the N-terminal half, and two serine/arginine-rich (SR) domains at the C-terminal half. The RRM is responsible for the binding of stem-loop I of U1 snRNA molecule. Additionally, the most prominent immunodominant region that can be recognized by auto-antibodies from autoimmune patients may be located within the RRM. The SR domains are involved in protein-protein interaction with SR proteins that mediate 5' splice site recognition [[cite:PUB00082757]]. For instance, the first SR domain is necessary and sufficient for ASF/SF2 binding [[cite:PUB00082759], [cite:PUB00082761]].</p> <p>Proteins containing this domain also includes Drosophila U1-70K that is an essential splicing factor required for viability in flies, but its SR domain is dispensable [[cite:PUB00082758]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | U1 snRNA binding | Interacting selectively and non-covalently with the U1 small nuclear RNA (U1 snRNA). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | U1 small nuclear ribonucleoprotein 70 kDa; TAIR: AT3G50670.1 U1 small nuclear ribonucleoprotein-70K; Swiss-Prot: sp|Q42404|RU17_ARATH U1 small nuclear ribonucleoprotein 70 kDa; TrEMBL-Plants: tr|A0A151QVV9|A0A151QVV9_CAJCA U1 small nuclear ribonucleoprotein 70 kDa; Found in the gene: LotjaGi4g1v0116300 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 100.00 |