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IPR034154 is a Archaeal primase DnaG/twinkle-like, TOPRIM domain.
<p>This topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain is found in archaeal DnaG-type primases and in mitochondrial twinkle helicase. In archaea, DnaG is tightly associated with the RNA-degrading exosome [[cite:PUB00074089], [cite:PUB00074085]]. DnaG of Sulfolobus solfataricus has been shown to exhibit primase activity in vitro [[cite:PUB00074084]]. Twinkle is needed for mitochondrial DNA replication and may be involved in recombinational repair of mitochondrial DNA [[cite:PUB00082776]].</p> <p>The TOPRIM domain has two conserved motifs, one of which centres at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in nucleotide polymerization by primases. The DXD motif may co-ordinate Mg<sup>2+</sup>, a cofactor required for full catalytic function [[cite:PUB00004485]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Nucleic acid-binding protein, putative; TAIR: AT1G30680.1 toprim domain-containing protein; Swiss-Prot: sp|B5X582|TWIH_ARATH Twinkle homolog protein, chloroplastic/mitochondrial; TrEMBL-Plants: tr|I3SNI9|I3SNI9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0266300 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01029 | CDD | 1 | 100.00 |