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IPR034168 is a Peptidyl-prolyl cis-trans isomerase E, RNA recognition motif.
<p>This entry represents the RNA recognition motif (RRM) of peptidyl-prolyl cis-trans isomerase E (PPIE, also known as Cyp33). PPIE is a nuclear RNA-binding cyclophilin with an N-terminal RNA recognition motif (RRM), and a C-terminal PPIase domain [[cite:PUB00036108]]. Cyp33 possesses RNA-binding activity and preferentially binds to polyribonucleotide polyA and polyU, but hardly to polyG and polyC. It binds specifically to mRNA, which can stimulate its PPIase activity. Moreover, Cyp33 interacts with the third plant homeodomain (PHD3) zinc finger cassette of the mixed lineage leukemia (MLL) proto-oncoprotein and a poly-A RNA sequence through its RRM domain [[cite:PUB00082799]]. It further mediates downregulation of the expression of MLL target genes HOXC8, HOXA9, CDKN1B, and C-MYC, in a proline isomerase-dependent manner [[cite:PUB00053930]]. Cyp33 also possesses a PPIase activity that catalyzes cis-trans isomerization of the peptide bond preceding a proline, which has been implicated in the stimulation of folding and conformational changes in folded and unfolded proteins. The PPIase activity can be inhibited by the immunosuppressive drug cyclosporin A [[cite:PUB00082800]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | RNA binding | Interacting selectively and non-covalently with an RNA molecule or a portion thereof. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | RNA binding; TAIR: AT1G13690.1 ATPase E1; Swiss-Prot: sp|A4FV72|PPIE_BOVIN Peptidyl-prolyl cis-trans isomerase E; TrEMBL-Plants: tr|A0A1J7GP09|A0A1J7GP09_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0292800 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 100.00 |