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IPR034291

Source: InterPro

Description

IPR034291 is a Thiamine phosphate synthase.

<p>Thiamine phosphate synthase (TPS), also known as thiamin phosphate pyrophosphorylase (TMP-PPase), catalyzes the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-hydroxyethyl)thiazole phosphate to yield thiamine phosphate in the thiamine biosynthesis pathway [[cite:PUB00005784]]. This family includes the thiamine-phosphate pyrophosphorylase, ThiE, of a number of bacteria [[cite:PUB00005854]], and N-terminal domains of bifunctional thiamine proteins of Saccharomyces cerevisiae and Schizosaccharomyces pombe, in which the C-terminal domain corresponds to the bacterial hydroxyethylthiazole kinase ThiM [[cite:PUB00002882]]. The plant enzyme is also bifunctional [[cite:PUB00017548]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004789
Molecular function Thiamine-phosphate diphosphorylase activity Catalysis of the reaction: 4-amino-2-methyl-5-diphosphomethylpyrimidine + 4-methyl-5-(2-phosphoethyl)-thiazole + H(+) = diphosphate + thiamine phosphate.
Subterm of
GO:0009228
Biological process Thiamine biosynthetic process The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.
Subterm of

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
LotjaGi6g1v0361800.1
– Thiamine-phosphate synthase; TAIR: AT1G22940.1 thiamin biosynthesis protein; Swiss-Prot: sp|Q5M731|TPS1L_ARATH Thiamine biosynthetic bifunctional enzyme TH1, chloroplastic; TrEMBL-Plants: tr|A0A151T846|A0A151T846_CAJCA Uncharacterized protein; Found in the gene: LotjaGi6g1v0361800
Domains
19

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd01169 CDD 1 100.00