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IPR034683 is a Cytidylyltransferase IspD/TarI.
<p>This family consists of cytidylyltransferases IspD and TarI and close homologues.</p> <p>2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (IspD) catalyses the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) in the deoxyxylulose pathway of isopentenyl diphosphate (IPP) biosynthesis [[cite:PUB00011033]]. This mevalonate independent pathway that utilizes pyruvate and glyceraldehydes 3-phosphate as starting materials for production of IPP occurs in a variety of bacteria, archaea and plant cells, but is absent in mammals. The isoprenoid pathway is a well known target for anti-infective drug development [[cite:PUB00043297], [cite:PUB00043298]]. In about twenty percent of bacterial genomes, this protein occurs as IspDF, a bifunctional fusion protein.</p> <p>Ribitol-5-phosphate cytidylyltransferase (TarI) is required for the synthesis of activated ribitol via the wall teichoic acid biosynthesis pathway. The enzyme catalyzes the transfer of the cytidylyl group of CTP to D-ribitol 5-phosphate to form CDP-ribitol [[cite:PUB00049880]].</p> <p>The human IspD (known as D-ribitol-5-phosphate cytidylyltransferase or isoprenoid synthase domain-containing protein) shows a canonical N-terminal cytidyltransferase domain linked to a C-terminal domain that is absent in cytidyltransferase homologues. It has cytidyltransferase activity toward pentose phosphates, including ribulose 5-phosphate, ribose 5-phosphate, and ribitol 5-phosphate. It is implicated in dystroglycan O-mannosylation [[cite:PUB00084173], [cite:PUB00084174]].</p> <p>D-fructose-6-phosphate cytidylyltransferase catalyses the formation of CDP-6-d-fructose from cytidine triphosphate and d-fructose-6-phosphate and is involved in the biosynthesis of capsular polysaccharides [[cite:PUB00154498]]. It could also utilise other sugar donors such as D-fructose-1-phosphate, D-glucose-6-phosphate, alpha-D-glucose-1-phosphate or D-glucitol-6-phosphate [[cite:PUB00154498]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Cytidylyltransferase activity | Catalysis of the transfer of a cytidylyl group to an acceptor. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; TAIR: AT2G02500.1 Nucleotide-diphospho-sugar transferases superfamily protein; Swiss-Prot: sp|P69834|ISPD_ARATH 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic; TrEMBL-Plants: tr|I3S1B8|I3S1B8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0002500 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd02516 | CDD | 1 | 100.00 |