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IPR001228 is a 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase.
<p>2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (IspD) catalyses the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) in the deoxyxylulose pathway of isopentenyl diphosphate (IPP) biosynthesis [[cite:PUB00011033]]. This mevalonate independent pathway that utilizes pyruvate and glyceraldehydes 3-phosphate as starting materials for production of IPP occurs in a variety of bacteria, archaea and plant cells, but is absent in mammals. The isoprenoid pathway is a well known target for anti-infective drug development [[cite:PUB00043297], [cite:PUB00043298]]. In about twenty percent of bacterial genomes, this protein occurs as IspDF, a bifunctional fusion protein.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Isoprenoid biosynthetic process | The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. | ||
| Molecular function | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity | Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + CTP = 4-CDP-2-C-methyl-D-erythritol + diphosphate. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic-like [Glycine max] gi|356563865|ref|XP_003550178.1| | 9 | ||
| – | PREDICTED: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic-like [Glycine max] gi|356563865|ref|XP_003550178.1| | 9 | ||
| – | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; TAIR: AT2G02500.1 Nucleotide-diphospho-sugar transferases superfamily protein; Swiss-Prot: sp|P69834|ISPD_ARATH 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic; TrEMBL-Plants: tr|I3S1B8|I3S1B8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0002500 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd02516 | CDD | 1 | 33.33 |