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IPR034870

Source: InterPro

Description

IPR034870 is a TAF15/EWS/TLS family.

<p>This entry represents the multi-functional TET (TAF15/EWS/TLS) or FET (FUS/EWS/TLS) protein family.</p> <p>TAF15/EWS/TLS family members include human FUS (Fused in liposarcoma), EWS (Ewing Sarcoma) and TAF15 (TATA binding associated factor 15), and the Drosophila orthologue Cabeza. They are RNA binding proteins that contain a transcriptional-activation domain (EAD), 3 glycine-arginine (RGG) rich regions, an RNA-binding domain (RBD), and a zinc finger domain [[cite:PUB00084538], [cite:PUB00084541]]. They are involved in transcription and alternative splicing. They are subjected to different environmental signals that induce post-translational modifications in their RBD and in the RGG domains, thus modulating their activity [[cite:PUB00084541]]. TAF15/EWS/TLS play important roles in oncogenesis and neuronal disease [[cite:PUB00084542]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003723
Molecular function RNA binding Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
Subterm of
GO:0006355
Biological process Regulation of transcription, DNA-templated Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
Subterm of
Regulates

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
LotjaGi2g1v0218700.1
– TATA-binding protein-associated factor 2N; TAIR: AT4G28990.1 RNA-binding protein-like protein; Swiss-Prot: sp|O95218|ZRAB2_HUMAN Zinc finger Ran-binding domain-containing protein 2; TrEMBL-Plants: tr|V7C3Z4|V7C3Z4_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0218700
Domains
11

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 100.00