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IPR035490 is a GlmS/FrlB, SIS domain 2.
<p>This entry represents the SIS (Sugar ISomerase) domain 2 found in glucosamine 6-phosphate synthase (GlmS) and fructosamine deglycase FrlB.</p> <p>GlmS contains a N-terminal glutaminase domain and C-terminal isomerase domain (consisting of two SIS domains) [[cite:PUB00005296]] and catalyzes the first step in hexosamine metabolism, converting fructose 6-phosphate into glucosamine 6-phosphate using glutamine as nitrogen source [[cite:PUB00085403]]. The glutaminase domain hydrolyzes glutamine to glutamate and ammonia. Ammonia is transferred through a channel to the isomerase domain for glucosamine 6-phosphate synthesis. In the absence of glutamine, GlmS catalyzes the isomerization of fructose 6-phosphate into glucose 6- phosphate [[cite:PUB00026574], [cite:PUB00085441], [cite:PUB00027397]].</p> <p>FrlB catalyses the conversion of a range of fructosamine 6-phosphates to glucose 6-phosphate and a free amino acid [[cite:PUB00056150]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Glutamine--fructose-6-phosphate aminotransferase [isomerizing]; TAIR: AT3G24090.1 putative glucosamine-fructose-6-phosphate aminotransferase; Swiss-Prot: sp|Q4KMC4|GFPT2_RAT Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2; TrEMBL-Plants: tr|G7KRK3|G7KRK3_MEDTR Glucosamine-fructose-6-phosphate aminotransferase; Found in the gene: LotjaGi1g1v0486600 | 19 | ||
| – | Glutamine--fructose-6-phosphate aminotransferase [isomerizing]; TAIR: AT3G24090.1 putative glucosamine-fructose-6-phosphate aminotransferase; Swiss-Prot: sp|Q4KMC4|GFPT2_RAT Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2; TrEMBL-Plants: tr|G7KRK3|G7KRK3_MEDTR Glucosamine-fructose-6-phosphate aminotransferase; Found in the gene: LotjaGi1g1v0486600 | 18 | ||
| – | Glutamine--fructose-6-phosphate aminotransferase [isomerizing]; TAIR: AT3G24090.1 putative glucosamine-fructose-6-phosphate aminotransferase; Swiss-Prot: sp|Q4KMC4|GFPT2_RAT Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2; TrEMBL-Plants: tr|G7KRK3|G7KRK3_MEDTR Glucosamine-fructose-6-phosphate aminotransferase; Found in the gene: LotjaGi1g1v0486600 | 18 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd05009 | CDD | 1 | 33.33 |