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IPR001347 is a SIS domain.
<p>The sugar isomerase (SIS) domain is a phosphosugar-binding module that is found in a variety of eubacterial, archaebacterial and eukaryotic proteins that have a role in phosphosugar isomerization or regulation [[cite:PUB00005498]]. In enzymes, the SIS domain can have a catalytic function as an isomerase and bind to phosphorylated sugars. In bacterial transcriptional regulators of the rpiR family, the domain seems to bind substrates implicated in the genes for sugar metabolism that are controlled by the regulator. The SIS domain is found in one or two copies and can be linked to additional domains, such as helix-turn-helix (HTH), CBS, glutamine amidotransferases type 2, or phosphopantetheine-attachment [[cite:PUB00005498], [cite:PUB00070737]].</p> <p>The SIS domain has an α-β structure and is dominated by a five-stranded parallel β-sheet flanked on either side by α-helices forming a three-layer α-β-α sandwich [[cite:PUB00005296]]. The fold shows similarities to that of glucose-6-phosphate isomerase.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Carbohydrate derivative binding | Interacting selectively and non-covalently with a carbohydrate derivative. | ||
| Biological process | Carbohydrate derivative metabolic process | The chemical reactions and pathways involving carbohydrate derivative. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: glutamine--fructose-6-phosphate aminotransferase [isomerizing] gi|502105634|ref|XP_004492850.1| | 18 | ||
| – | PREDICTED: glutamine--fructose-6-phosphate aminotransferase [isomerizing] gi|502105634|ref|XP_004492850.1| | 16 | ||
| – | PREDICTED: probable arabinose 5-phosphate isomerase-like [Cicer arietinum] gi|502110037|ref|XP_004493784.1| | 16 | ||
| – | Glutamine--fructose-6-phosphate aminotransferase [isomerizing]; TAIR: AT3G24090.1 putative glucosamine-fructose-6-phosphate aminotransferase; Swiss-Prot: sp|Q4KMC4|GFPT2_RAT Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2; TrEMBL-Plants: tr|G7KRK3|G7KRK3_MEDTR Glucosamine-fructose-6-phosphate aminotransferase; Found in the gene: LotjaGi1g1v0486600 | 19 | ||
| – | Glutamine--fructose-6-phosphate aminotransferase [isomerizing]; TAIR: AT3G24090.1 putative glucosamine-fructose-6-phosphate aminotransferase; Swiss-Prot: sp|Q4KMC4|GFPT2_RAT Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2; TrEMBL-Plants: tr|G7KRK3|G7KRK3_MEDTR Glucosamine-fructose-6-phosphate aminotransferase; Found in the gene: LotjaGi1g1v0486600 | 18 | ||
| – | Glutamine--fructose-6-phosphate aminotransferase [isomerizing]; TAIR: AT3G24090.1 putative glucosamine-fructose-6-phosphate aminotransferase; Swiss-Prot: sp|Q4KMC4|GFPT2_RAT Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2; TrEMBL-Plants: tr|G7KRK3|G7KRK3_MEDTR Glucosamine-fructose-6-phosphate aminotransferase; Found in the gene: LotjaGi1g1v0486600 | 18 | ||
| – | Arabinose 5-phosphate isomerase, putative; TAIR: AT3G54690.1 Sugar isomerase (SIS) family protein; Swiss-Prot: sp|Q9M1T1|SETH3_ARATH Probable arabinose 5-phosphate isomerase; TrEMBL-Plants: tr|A0A072UDP6|A0A072UDP6_MEDTR Arabinose 5-phosphate isomerase, putative; Found in the gene: LotjaGi1g1v0708000 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd05014 | CDD | 1 | 14.29 |