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IPR035911 is a MurE/MurF, N-terminal.
<p>The MurF protein contains three domains. The N-terminal domain consists of a small α/β fold and contacts the larger central domain across a broad hydrophobic interface. The central domain and the C-terminal domain adopt mononucleotide and dinucleotide (Rossmann) folds, respectively, and are connected by a short linker peptide that is poorly ordered in the crystal [[cite:PUB00035791]].</p> <p>This superfamily represents the N-terminal domain of the MurE/F proteins. They are ligases involved in the formation of UDP-N-acetylmuramyl-pentapeptide [[cite:PUB00035791]] and have been considered as antibacterial targets [[cite:PUB00086526]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase; TAIR: AT1G63680.1 ALBINO OR PALE-GREEN 13; Swiss-Prot: sp|Q03523|MURE_BACSU UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase; TrEMBL-Plants: tr|A0A072U5D4|A0A072U5D4_MEDTR UDP-N-acetylmuramyl-tripeptide synthetase; Found in the gene: LotjaGi4g1v0427200 | 27 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 100.00 |