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IPR036428

Source: InterPro

Description

IPR036428 is a Pterin 4 alpha carbinolamine dehydratase superfamily.

<p>DCoH has a β(2)-α-β(2)-α fold arranged in two α/β layers.</p> <p>Pterin 4 alpha carbinolamine dehydratase is also known as DCoH. DCoH is the dimerisation cofactor of hepatocyte nuclear factor 1 (HNF-1) that functions as both a transcriptional coactivator and a pterin dehydratase [[cite:PUB00005041]]. X-ray crystallographic studies have shown that the ligand binds at four sites per tetrameric enzyme, with little apparent conformational change in the protein.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0006729
Biological process Tetrahydrobiopterin biosynthetic process The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine.
Subterm of
GO:0008124
Molecular function 4-alpha-hydroxytetrahydrobiopterin dehydratase activity Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H(2)O.
Subterm of

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
LotjaGi6g1v0018700.1
– Pterin-4-alpha-carbinolamine dehydratase; TAIR: AT5G51110.1 Transcriptional coactivator/pterin dehydratase; Swiss-Prot: sp|B0JQV0|PHS_MICAN Putative pterin-4-alpha-carbinolamine dehydratase; TrEMBL-Plants: tr|I3SZ80|I3SZ80_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0018700
Domains
7

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SSF55248 SUPERFAMILY 1 100.00