Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message

IPR036569

Source: InterPro

Description

IPR036569 is a Sugar-phosphate isomerase, RpiB/LacA/LacB superfamily.

<p>This entry represents the sugar isomerase enzymes ribose 5-phosphate isomerase B (RpiB), galactose isomerase subunit A (LacA) and galactose isomerase subunit B (LacB).</p> <p>Galactose-6-phosphate isomerase ([ec:5.3.1.26]) is a heteromultimeric protein consisting of subunits LacA and LacB, and catalyses the conversion of D-galactose 6-phosphate to D-tagatose and 6-phosphate in the tagatose 6-phosphate pathway of lactose catabolism [[cite:PUB00002200]]. Galactose-6-phosphate isomerase is induced by galactose or lactose.</p> <p>Ribose 5-phosphate isomerase ([ec:5.3.1.6]) forms a homodimer and catalyses the interconversion of D-ribose 5-phosphate and D-ribulose 5-phosphate in the non-oxidative branch of the pentose phosphate pathway. This reaction permits the synthesis of ribose from other sugars, as well as the recycling of sugars from nucleotide breakdown. Two unrelated enzymes can catalyse this reaction: RpiA (found in most organisms) and RpiB (found in some bacteria and eukaryotes). RpiB is also involved in metabolism of the rare sugar, allose, in addition to ribose sugars. The structures of RpiA and RpiB are distinct, RpiB having a Rossmann-type α/β/α sandwich topology [[cite:PUB00029142]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0005975
Biological process Carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.
Subterm of
GO:0016853
Molecular function Isomerase activity Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.
Subterm of

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
LotjaGi1g1v0779400.1
– Galactose-6-phosphate isomerase subunit LacB; TAIR: AT3G04880.1 DNA-damage-repair/toleration protein (DRT102); Swiss-Prot: sp|Q05212|DR102_ARATH DNA damage-repair/toleration protein DRT102; TrEMBL-Plants: tr|I1NC74|I1NC74_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0779400
Domains
15

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SSF89623 SUPERFAMILY 1 100.00