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IPR036790 is a Frizzled cysteine-rich domain superfamily.
<p>This entry represents the frizzled domain superfamily.</p> <p>The frizzled (fz) domain is an extracellular domain of about 120 amino acids.It was first identified in the alpha-1 chain of type XVIII collagen and in members of the Frizzled family of seven transmembrane (7TM) proteins which act as receptors for secreted Wingless (Wg)/Wnt glycoproteins [[cite:PUB00033721]]. In addition to these proteins, one or two copies of the fz domain are also found [[cite:PUB00001039], [cite:PUB00033661], [cite:PUB00033662], [cite:PUB00005486], [cite:PUB00033722]] in: <ul> <li>The Frzb family; secreted frizzled-like proteins.</li> <li>Smoothened; another 7TM receptor involved in hedgehog signaling.</li> <li>Carboxpeptidase Z (CPZ).</li> <li>Transmembrane serine protease corin (atrial natriuretic peptide-converting enzyme).</li> <li>Two receptor tyrosine kinases (RTKs) subfamilies, the Ror family and the muscle-specific kinase (MuSK) family.</li> </ul> </p> <p>As the fz domain contains 10 cysteines which are largely conserved, it has also been called cysteine-rich domain (CRD) [[cite:PUB00033721]]. The fz domain also contains several other highly conserved residues, for example, a basic amino acid follows C6, and a conserved proline residues lies four residues C-terminal to C9 [[cite:PUB00005486]]. The crystal structure of a fz domain shows that it is predominantly α-helical with all cysteines forming disulphide bonds. In addition to helical regions, two short β-strands at the N terminus form a minimal β-sheet with the second β sheet passing through a knot created by disulphide bonds [[cite:PUB00033723]].</p> <p>Several fz domains have been shown to be both necessary and sufficient for Wg/Wnt ligand binding, strongly suggesting that the fz domain is a Wg/Wnt interacting domain [[cite:PUB00004238], [cite:PUB00033724]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Protein binding | Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Metalloendopeptidase/zinc ion-binding protein; TAIR: AT5G42620.1 metalloendopeptidase / zinc ion binding protein; Swiss-Prot: sp|Q08875|SUHW_DROAN Protein suppressor of hairy wing; TrEMBL-Plants: tr|A0A0B2PA32|A0A0B2PA32_GLYSO Leishmanolysin-like peptidase; Found in the gene: LotjaGi1g1v0417600 | 5 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF63501 | SUPERFAMILY | 1 | 100.00 |