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IPR036858

Source: InterPro

Description

IPR036858 is a Cyclin-dependent kinase, regulatory subunit superfamily.

<p>In eukaryotes, cyclin-dependent protein kinases interact with cyclins to regulate cell cycle progression, and are required for the G1 and G2 stages of cell division [[cite:PUB00001157]]. The proteins bind to a regulatory subunit, cyclin-dependent kinase regulatory subunit (CKS), which is essential for their function. This regulatory subunit is a small protein of 79 to 150 residues. In yeast (gene CKS1) and in fission yeast (gene suc1) a single isoform is known, while mammals have two highly related isoforms. The regulatory subunits exist as hexamers, formed by the symmetrical assembly of 3 interlocked homodimers, creating an unusual 12-stranded β-barrel structure [[cite:PUB00005179]]. Through the barrel centre runs a 12A diameter tunnel, lined by 6 exposed helix pairs [[cite:PUB00001914]]. Six kinase units can be modelled to bind the hexameric structure, which may thus act as a hub for cyclin-dependent protein kinase multimerisation [[cite:PUB00001914], [cite:PUB00005179]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0016538
Molecular function Cyclin-dependent protein serine/threonine kinase regulator activity Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins.
Subterm of

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
LotjaGi3g1v0484000.1
– Cyclin-dependent kinases regulatory subunit; TAIR: AT2G27960.1 cyclin-dependent kinase-subunit 1; Swiss-Prot: sp|O23249|CKS1_ARATH Cyclin-dependent kinases regulatory subunit 1; TrEMBL-Plants: tr|A0A1J7I6Q1|A0A1J7I6Q1_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0484000
Domains
10

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SSF55637 SUPERFAMILY 1 100.00