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IPR037094 is a Glycoside hydrolase family 38, central domain superfamily.
<p>This entry represents a domain superfamily found in members of the glycosyl hydrolases families 38. This domain is found in the central region that adopts a structure consisting of three α helices, in an immunoglobulin/albumin-binding domain-like fold. The domain is predominantly found in the enzyme alpha-mannosidase [[cite:PUB00022319]].</p> <p>Glycoside hydrolase family 38 [cazy:GH38] comprises enzymes with only one known activity; alpha-mannosidase ([ec:3.2.1.24]) ([ec:3.2.1.114]).</p> <p>Lysosomal alpha-mannosidase is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. The enzyme catalyses the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides, and can cleave all known types of alpha-mannosidic linkages. Defects in the gene cause lysosomal alpha-mannosidosis (AM), a lysosomal storage disease characterised by the accumulation of unbranched oligo-saccharide chains.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Alpha-mannosidase activity | Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. | ||
| Biological process | Mannose metabolic process | The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Alpha-mannosidase; TAIR: AT5G13980.1 Glycosyl hydrolase family 38 protein; Swiss-Prot: sp|Q8LPJ3|MANA2_ARATH Probable alpha-mannosidase At5g13980; TrEMBL-Plants: tr|I1JXQ5|I1JXQ5_SOYBN Alpha-mannosidase; Found in the gene: LotjaGi1g1v0333500 | 33 | ||
| – | Alpha-mannosidase; TAIR: AT5G13980.1 Glycosyl hydrolase family 38 protein; Swiss-Prot: sp|Q8LPJ3|MANA2_ARATH Probable alpha-mannosidase At5g13980; TrEMBL-Plants: tr|I1JXQ5|I1JXQ5_SOYBN Alpha-mannosidase; Found in the gene: LotjaGi1g1v0333500 | 26 | ||
| – | Alpha-mannosidase; TAIR: AT5G13980.1 Glycosyl hydrolase family 38 protein; Swiss-Prot: sp|Q8LPJ3|MANA2_ARATH Probable alpha-mannosidase At5g13980; TrEMBL-Plants: tr|I1ML97|I1ML97_SOYBN Alpha-mannosidase; Found in the gene: LotjaGi1g1v0632800 | 33 | ||
| – | Alpha-mannosidase; TAIR: AT3G26720.1 Glycosyl hydrolase family 38 protein; Swiss-Prot: sp|P94078|MANA1_ARATH Alpha-mannosidase At3g26720; TrEMBL-Plants: tr|G7KX96|G7KX96_MEDTR Alpha-mannosidase; Found in the gene: LotjaGi1g1v0632900 | 32 | ||
| – | Alpha-mannosidase; TAIR: AT5G14950.1 golgi alpha-mannosidase II; Swiss-Prot: sp|Q9LFR0|GMAN2_ARATH Alpha-mannosidase 2; TrEMBL-Plants: tr|G7KJH1|G7KJH1_MEDTR Alpha-mannosidase; Found in the gene: LotjaGi2g1v0252400 | 28 | ||
| – | Alpha-mannosidase; TAIR: AT5G14950.1 golgi alpha-mannosidase II; Swiss-Prot: sp|Q9LFR0|GMAN2_ARATH Alpha-mannosidase 2; TrEMBL-Plants: tr|K7LXD4|K7LXD4_SOYBN Alpha-mannosidase; Found in the gene: LotjaGi2g1v0252400 | 22 | ||
| – | Alpha-mannosidase; TAIR: AT5G66150.2 Glycosyl hydrolase family 38 protein; Swiss-Prot: sp|C0HJB3|MANA_CANEN Alpha-mannosidase; TrEMBL-Plants: tr|G7LB83|G7LB83_MEDTR Alpha-mannosidase; Found in the gene: LotjaGi4g1v0129600 | 32 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd10810 | CDD | 1 | 14.29 |