Description

IPR037446 is a Histidine acid phosphatase, VIP1 family.

<p>This entry represents the VIP1 subfamily of the histidine acid phosphatase family. Budding yeast Vip1 is a inositol hexakisphosphate and inositol heptakisphosphate kinase [[cite:PUB00071752]]. The N-terminal domain of yeast Vip1 has inositol-hexakisphosphate kinase activity and is followed by a phosphatase domain of as yet unknown specificity, but which is very likely to act on multiply phosphorylated inositol species [[cite:PUB00053493]].</p> <p>The histidine phosphatase superfamily is so named because catalysis centres on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The relationship between the two branches is not evident by (PSI-)BLAST but is clear from more sensitive sequence searches and structural comparisons [[cite:PUB00053493]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 27

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: