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IPR037528 is a Acetylglutamate kinase ArgB.
<p>N -Acetylglutamate (NAG) fulfils distinct biological roles in lower and higher organisms. In prokaryotes, lower eukaryotes and plants it is the first intermediate in the biosynthesis of arginine, whereas in ureotelic (excreting nitrogen mostly in the form of urea) vertebrates, it is an essential allosteric cofactor for carbamyl phosphate synthetase I (CPSI), the first enzyme of the urea cycle. The pathway that leads from glutamate to arginine in lower organisms employs eight steps, starting with the acetylation of glutamate to form NAG. In these species, NAG can be produced by two enzymatic reactions: one catalysed by NAG synthase (NAGS) and the other by ornithine acetyltransferase (OAT). In ureotelic species, NAG is produced exclusively by NAGS. In lower organisms, NAGS is feedback-inhibited by L-arginine, whereas mammalian NAGS activity is significantly enhanced by this amino acid. The NAGS genes of bacteria, fungi and mammals are more diverse than other arginine-biosynthesis and urea-cycle genes. The evolutionary relationship between the distinctly different roles of NAG and its metabolism in lower and higher organisms remains to be determined [[cite:PUB00014499]].</p> <p>The pathway from glutamate to arginine is:</p> <ul> <li>NAGS; N-acetylglutamate synthase ([ec:2.3.1.1]) (glutamate to N-acetylglutamate)</li> <li>NAGK; N-acetylglutamate kinase ([ec:2.7.2.8]) (N-acetylglutamate to N-acetylglutamate-5P)</li> <li>N-acetyl-gamma-glutamyl-phosphate reductase ([ec:1.2.1.38]) (N-acetylglutamate-5P to N-acetylglumate semialdehyde)</li> <li>Acetylornithine aminotransferase ([ec:2.6.1.11]) (N-acetylglumate semialdehyde to N-acetylornithine)</li> <li>Acetylornithine deacetylase ([ec:3.5.1.16]) (N-acetylornithine to ornithine)</li> <li>Arginase ([ec:3.5.3.1]) (ornithine to arginine)</li></ul> <p>This family represents acetylglutamate kinase ArgB ([ec:2.7.2.8]).</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Acetylglutamate kinase activity | Catalysis of the reaction: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate-5-phosphate. | ||
| Biological process | Arginine biosynthetic process | The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Acetylglutamate kinase; TAIR: AT3G57560.1 N-acetyl-l-glutamate kinase; Swiss-Prot: sp|Q9SCL7|NAGK_ARATH Acetylglutamate kinase, chloroplastic; TrEMBL-Plants: tr|I1K925|I1K925_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0391300 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd04250 | CDD | 1 | 100.00 |