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IPR010167 is a Amino-acid N-acetyltransferase.
<p>This entry represents amino-acid N-acetyltransferase or N-acetylglutamate synthase, which is the product of the argA gene and the first enzyme in arginine biosynthesis. This enzyme displays more diversity between bacteria, fungi and mammals than other enzymes in arginine metabolism, and N-acetylglutamate itself can have different roles in different taxonomic groups: in prokaryotes, lower eukaryotes and plants it is the first intermediate in arginine biosynthesis, while in vertebrates it is an allosteric cofactor for the first enzyme in the urea cycle [[cite:PUB00014499]]. In bacteria, arginine can regulate ornithine biosynthesis via a feedback inhibition mechanism [[cite:PUB00014891]]. This enzyme may also act on aspartate.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Acetyl-CoA:L-glutamate N-acetyltransferase activity | Catalysis of the reaction: L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+). | ||
| Cellular component | Cytoplasm | All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. | ||
| Biological process | Arginine biosynthetic process | The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: acetylglutamate kinase, chloroplastic-like [Glycine max] gi|356515515|ref|XP_003526445.1| | 14 | ||
| – | PREDICTED: amino-acid acetyltransferase-like isoform X1 [Cicer arietinum] gi|502160640|ref|XP_004511825.1| | 19 | ||
| – | PREDICTED: amino-acid acetyltransferase-like [Glycine max] gi|356565491|ref|XP_003550973.1| | 17 | ||
| – | Acetylglutamate kinase; TAIR: AT3G57560.1 N-acetyl-l-glutamate kinase; Swiss-Prot: sp|Q9SCL7|NAGK_ARATH Acetylglutamate kinase, chloroplastic; TrEMBL-Plants: tr|I1K925|I1K925_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0391300 | 17 | ||
| – | Acetylglutamate kinase; TAIR: AT4G37670.2 N-acetyl-l-glutamate synthase 2; Swiss-Prot: sp|B5X4Z4|NAGS2_ARATH Probable amino-acid acetyltransferase NAGS2, chloroplastic; TrEMBL-Plants: tr|I1J9F4|I1J9F4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0410400 | 18 | ||
| – | Acetylglutamate kinase; TAIR: AT4G37670.2 N-acetyl-l-glutamate synthase 2; Swiss-Prot: sp|B5X4Z4|NAGS2_ARATH Probable amino-acid acetyltransferase NAGS2, chloroplastic; TrEMBL-Plants: tr|I1J9F5|I1J9F5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0410400 | 18 | ||
| – | Acetylglutamate kinase; TAIR: AT4G37670.2 N-acetyl-l-glutamate synthase 2; Swiss-Prot: sp|B5X4Z4|NAGS2_ARATH Probable amino-acid acetyltransferase NAGS2, chloroplastic; TrEMBL-Plants: tr|A0A1J7GRY4|A0A1J7GRY4_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0094000 | 19 | ||
| – | Acetylglutamate kinase; TAIR: AT4G37670.2 N-acetyl-l-glutamate synthase 2; Swiss-Prot: sp|B5X4Z4|NAGS2_ARATH Probable amino-acid acetyltransferase NAGS2, chloroplastic; TrEMBL-Plants: tr|K7MLX9|K7MLX9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0094000 | 18 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd04301 | CDD | 1 | 12.50 |