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IPR037607 is a Diacylglycerol kinase.
<p>Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. Upon cell stimulation, diacylglycerol kinase (DGK) converts DAG into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity [[cite:PUB00087376], [cite:PUB00044044]]. Most vertebrate species contain 10 different DGK isozymes. The catalytic domain constitutes the single largest sequence element within the DGK proteins that is commonly and uniquely shared by all family members [[cite:PUB00044044]]. DGK proteins can be classified into five classes based on the presence or absence of specific functional domains. DGKs play an important role in controlling diverse cellular processes including development, cell division and proliferation, neuronal and immune responses, vascular traffic, apoptosis and cytoskeletal reorganization [[cite:PUB00087377]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Diacylglycerol kinase activity | Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate. | ||
| Biological process | Signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Diacylglycerol kinase; TAIR: AT2G20900.2 diacylglycerol kinase 5; Swiss-Prot: sp|Q9C5E5|DGK5_ARATH Diacylglycerol kinase 5; TrEMBL-Plants: tr|V7AIU3|V7AIU3_PHAVU Diacylglycerol kinase; Found in the gene: LotjaGi3g1v0325600 | 16 | ||
| – | Diacylglycerol kinase; TAIR: AT2G20900.2 diacylglycerol kinase 5; Swiss-Prot: sp|Q9C5E5|DGK5_ARATH Diacylglycerol kinase 5; TrEMBL-Plants: tr|V7AIU3|V7AIU3_PHAVU Diacylglycerol kinase; Found in the gene: LotjaGi3g1v0325600 | 16 | ||
| – | Diacylglycerol kinase; TAIR: AT2G20900.2 diacylglycerol kinase 5; Swiss-Prot: sp|Q9C5E5|DGK5_ARATH Diacylglycerol kinase 5; TrEMBL-Plants: tr|I3SNA3|I3SNA3_MEDTR Diacylglycerol kinase; Found in the gene: LotjaGi3g1v0439300 | 18 | ||
| – | Diacylglycerol kinase; TAIR: AT2G20900.2 diacylglycerol kinase 5; Swiss-Prot: sp|Q9C5E5|DGK5_ARATH Diacylglycerol kinase 5; TrEMBL-Plants: tr|I3SNA3|I3SNA3_MEDTR Diacylglycerol kinase; Found in the gene: LotjaGi3g1v0439300 | 18 | ||
| – | Diacylglycerol kinase; TAIR: AT2G20900.2 diacylglycerol kinase 5; Swiss-Prot: sp|Q9C5E5|DGK5_ARATH Diacylglycerol kinase 5; TrEMBL-Plants: tr|I3SNA3|I3SNA3_MEDTR Diacylglycerol kinase; Found in the gene: LotjaGi3g1v0439300 | 18 | ||
| – | Diacylglycerol kinase; TAIR: AT2G20900.2 diacylglycerol kinase 5; Swiss-Prot: sp|Q9C5E5|DGK5_ARATH Diacylglycerol kinase 5; TrEMBL-Plants: tr|A0A072UKH9|A0A072UKH9_MEDTR Diacylglycerol kinase; Found in the gene: LotjaGi3g1v0459600 | 18 | ||
| – | Diacylglycerol kinase; TAIR: AT5G07920.1 diacylglycerol kinase1; Swiss-Prot: sp|Q39017|DGK1_ARATH Diacylglycerol kinase 1; TrEMBL-Plants: tr|A0A151SL25|A0A151SL25_CAJCA Diacylglycerol kinase; Found in the gene: LotjaGi4g1v0253500 | 26 | ||
| – | Diacylglycerol kinase; TAIR: AT5G07920.1 diacylglycerol kinase1; Swiss-Prot: sp|Q39017|DGK1_ARATH Diacylglycerol kinase 1; TrEMBL-Plants: tr|A0A151SL25|A0A151SL25_CAJCA Diacylglycerol kinase; Found in the gene: LotjaGi4g1v0253500 | 26 | ||
| – | Diacylglycerol kinase; TAIR: AT4G30340.1 diacylglycerol kinase 7; Swiss-Prot: sp|F4JQ95|DGK7_ARATH Diacylglycerol kinase 7; TrEMBL-Plants: tr|I1LVU7|I1LVU7_SOYBN Diacylglycerol kinase; Found in the gene: LotjaGi4g1v0295700 | 16 | ||
| – | Diacylglycerol kinase; TAIR: AT5G63770.1 diacylglycerol kinase 2; Swiss-Prot: sp|Q9FFN7|DGK2_ARATH Diacylglycerol kinase 2; TrEMBL-Plants: tr|I1K533|I1K533_SOYBN Diacylglycerol kinase; Found in the gene: LotjaGi4g1v0414600 | 26 | ||
| – | Diacylglycerol kinase; TAIR: AT5G57690.1 diacylglycerol kinase 4; Swiss-Prot: sp|Q1PDI2|DGK4_ARATH Diacylglycerol kinase 4; TrEMBL-Plants: tr|K7MS66|K7MS66_SOYBN Diacylglycerol kinase; Found in the gene: LotjaGi6g1v0198000 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF111331 | SUPERFAMILY | 1 | 9.09 |