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IPR002219 is a Protein kinase C-like, phorbol ester/diacylglycerol-binding domain.
<p>Diacylglycerol (DAG) is an important second messenger. Phorbol esters (PE) are analogues of DAG and potent tumour promoters that cause a variety of physiological changes when administered to both cells and tissues. DAG activates a family of serine/threonine protein kinases, collectively known as protein kinase C (PKC) [[cite:PUB00001427]]. Phorbol esters can directly stimulate PKC. The N-terminal region of PKC, known as C1, has been shown [[cite:PUB00004685]] to bind PE and DAG in a phospholipid and zinc-dependent fashion. The C1 region contains one or two copies (depending on the isozyme of PKC) of a cysteine-rich domain, which is about 50 amino-acid residues long, and which is essential for DAG/PE-binding. The DAG/PE-binding domain binds two zinc ions; the ligands of these metal ions are probably the six cysteines and two histidines that are conserved in this domain.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: probable nucleoredoxin 3-like [Glycine max] gi|356515549|ref|XP_003526462.1| | 15 | ||
| – | Cysteine/Histidine-rich C1 domain family protein [Theobroma cacao] gi|508705322|gb|EOX97218.1| | 8 | ||
| – | PREDICTED: diacylglycerol kinase 1-like [Glycine max] gi|356562607|ref|XP_003549561.1| | 23 | ||
| – | PREDICTED: diacylglycerol kinase 1-like [Glycine max] gi|356562607|ref|XP_003549561.1| | 22 | ||
| – | PREDICTED: diacylglycerol kinase 1-like [Glycine max] gi|356512878|ref|XP_003525142.1| | 19 | ||
| – | Phd finger protein, putative; TAIR: AT1G77800.1 PHD finger family protein; Swiss-Prot: sp|Q7YZH1|RNO_DROME PHD finger protein rhinoceros; TrEMBL-Plants: tr|A0A0R0KNZ6|A0A0R0KNZ6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0249800 | 27 | ||
| – | Cysteine/histidine-rich C1 domain protein; TAIR: AT2G16050.1 Cysteine/Histidine-rich C1 domain family protein; Swiss-Prot: sp|Q7Y0E8|NRX11_ORYSJ Probable nucleoredoxin 1-1; TrEMBL-Plants: tr|A0A0L9V791|A0A0L9V791_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0504200 | 9 | ||
| – | Diacylglycerol kinase; TAIR: AT5G07920.1 diacylglycerol kinase1; Swiss-Prot: sp|Q39017|DGK1_ARATH Diacylglycerol kinase 1; TrEMBL-Plants: tr|A0A151SL25|A0A151SL25_CAJCA Diacylglycerol kinase; Found in the gene: LotjaGi4g1v0253500 | 26 | ||
| – | Diacylglycerol kinase; TAIR: AT5G07920.1 diacylglycerol kinase1; Swiss-Prot: sp|Q39017|DGK1_ARATH Diacylglycerol kinase 1; TrEMBL-Plants: tr|A0A151SL25|A0A151SL25_CAJCA Diacylglycerol kinase; Found in the gene: LotjaGi4g1v0253500 | 26 | ||
| – | Diacylglycerol kinase; TAIR: AT5G63770.1 diacylglycerol kinase 2; Swiss-Prot: sp|Q9FFN7|DGK2_ARATH Diacylglycerol kinase 2; TrEMBL-Plants: tr|I1K533|I1K533_SOYBN Diacylglycerol kinase; Found in the gene: LotjaGi4g1v0414600 | 26 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 10.00 |