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IPR037930 is a Tom40.
<p>Tom40 forms a channel in the mitochondrial outer membrane with a pore about 1.5 to 2.5 nanometers wide. It functions as a transport channel for unfolded protein chains and forms a complex with Tom5, Tom6, Tom7, and Tom22. The primary receptors Tom20 and Tom70 recruit the unfolded precursor protein from the mitochondrial-import stimulating factor (MSF) or cytosolic Hsc70. The precursor passes through the Tom40 channel and through another channel in the inner membrane, formed by Tim23, to be finally translocated into the mitochondrial matrix. The process depends on a proton motive force across the inner membrane and requires a contact site where the outer and inner membranes come close [[cite:PUB00087883]]. Tom40 is also involved in inserting outer membrane proteins into the membrane, most likely not via a lateral opening in the pore, but by transfering precursor proteins to an outer membrane sorting and assembly machinery [[cite:PUB00087884]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Mitochondrial outer membrane | The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. | ||
| Molecular function | Protein transmembrane transporter activity | Enables the transfer of a protein from one side of a membrane to the other. | ||
| Biological process | Protein import into mitochondrial matrix | The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Mitochondrial import receptor subunit tom40, putative; TAIR: AT3G20000.1 translocase of the outer mitochondrial membrane 40; Swiss-Prot: sp|Q9LHE5|TO401_ARATH Mitochondrial import receptor subunit TOM40-1; TrEMBL-Plants: tr|I3TAE4|I3TAE4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0459300 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd07305 | CDD | 1 | 100.00 |