Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR039128 is a Activating signal cointegrator 1-like.
<p>Activating signal cointegrator 1 (TRIP4) is a transcription coactivator that interacts with nuclear receptors, including thyroid hormone receptor [[cite:PUB00071531]], the androgen receptor [[cite:PUB00088960]] and ESR1 [[cite:PUB00071531]], provided ligand is bound to the receptor. This interaction facilitates nuclear receptor-mediated transcription. TRIP4 contains a C4-type zinc finger. It is polyufmylated by the UFM1-conjugating system and deufmylated by the protease UFSP2; ufmylation promotes the recruitment of additional transcriptional coactivators [[cite:PUB00088961]]. TRIP4 also functions as part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation [[cite:PUB00151150], [cite:PUB00151151], [cite:PUB00151152]].</p> <p>This entry also includes TRIP4 orthologues from yeast, RQT4, which is part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation [[cite:PUB00099554]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Activating signal cointegrator 1; TAIR: AT3G47610.1 transcription regulator/ zinc ion binding protein; Swiss-Prot: sp|Q15650|TRIP4_HUMAN Activating signal cointegrator 1; TrEMBL-Plants: tr|V7CDE8|V7CDE8_PHAVU Uncharacterized protein; Found in the gene: LotjaGi4g1v0248600 | 7 | ||
| – | Activating signal cointegrator 1; TAIR: AT2G20410.1 RNA-binding ASCH domain protein; Swiss-Prot: sp|Q9QXN3|TRIP4_MOUSE Activating signal cointegrator 1; TrEMBL-Plants: tr|I1LBR5|I1LBR5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0207300 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 50.00 |