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IPR039171

Source: InterPro

Description

IPR039171 is a Pre-mRNA-splicing factor Cwc2/Slt11.

<p>This entry contains proteins involved in the first step of pre-mRNA splicing to remove introns. Splicing is performed by the spliceosome, which is a complex of snRNAs U1, U2, U4, U5, and U6 and proteins such as pre-mRNA-processing factor 19 (Prp19). The yeast protein Cwc2 contains motifs known to bind RNA, a zinc finger and an RNA recognition motif. Because mutations in the gene are lethal and lead to accumulation of pre-mRNA, and reduced levels of U1, U4, U5 and U6 snRNAs and U4/U6 snRNA complex levels, Cwc2 has been proposed to link the Prp19 complex to the spliceosome during pre-mRNA splicing [[cite:PUB00082819]]. Because Cwc2 is at the spliceosome catalytic centre, it induces an active conformation of the spliceosome's catalytic RNA elements [[cite:PUB00089039]]. Cwc2 is a component of the CWC complex [[cite:PUB00008533]]. The human homologue, known as RBM22 [[cite:PUB00089039]], also translocates the protein SLU7 from the nucleus to the cytoplasm or vice versa in the case of the calcium-binding protein PDCD6 [[cite:PUB00089042]].</p> <p>Also included in this entry is the pre-mRNA-splicing factor Slt11 (also known as Ecm2) [[cite:PUB00089043]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003723
Molecular function RNA binding Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
Subterm of

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
LotjaGi6g1v0192500.1
– Zinc finger CCCH domain protein; TAIR: AT1G07360.1 CCCH-type zinc fingerfamily protein with RNA-binding domain-containing protein; Swiss-Prot: sp|Q5SNN4|C3H40_ORYSJ Zinc finger CCCH domain-containing protein 40; TrEMBL-Plants: tr|A0A0B2SAY9|A0A0B2SAY9_GLYSO Zinc finger CCCH domain-containing protein 40; Found in the gene: LotjaGi6g1v0192500
Domains
21

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 100.00