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IPR039245

Source: InterPro

Description

IPR039245 is a Peroxisomal/glyoxysomal leader peptide-processing protease.

<p>The peroxisomal leader peptide-processing protease (TYSND1, trypsin domain-containing 1) removes the N-terminal transit peptide from proteins containing a PTS2 target sequence [[cite:PUB00089352]]. The plant glyoxysomal processing protease (DEG15) performs a similar function in the glyoxysome, a specialized peroxisome. DEG15 exists as a homodimer or as a monomer; as a dimer it is a processing enzyme, as a monomer it degrades denatured proteins [[cite:PUB00089353]]. These peptidases are trypsin homologues and members of MEROPS family S1 and subfamily S1B. Cleavage requires a cysteine residue in P1 or P2 [[cite:PUB00089353]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004252
Molecular function Serine-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
Subterm of
GO:0005777
Cellular component Peroxisome A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
Subterm of
GO:0016485
Biological process Protein processing Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
Subterm of

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
LotjaGi6g1v0329800.2
– Glyoxysomal processing protease, glyoxysomal-like protein; TAIR: AT1G28320.1 protease-like protein; Swiss-Prot: sp|Q8VZD4|DEG15_ARATH Glyoxysomal processing protease, glyoxysomal; TrEMBL-Plants: tr|G7ISD6|G7ISD6_MEDTR Glyoxysomal processing protease, glyoxysomal-like protein; Found in the gene: LotjaGi6g1v0329800
Domains
8

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SSF50494 SUPERFAMILY 1 100.00