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IPR043504 is a Peptidase S1, PA clan, chymotrypsin-like fold.
<p>This entry represents the chymotrypsin-like fold found in proteins from MEROPS peptidase family S1 (clan PA). The PA clan contains both cysteine and serine proteases that can be found in plants, animals, fungi, eubacteria, archaea and viruses [[cite:PUB00004667]].</p> <p>The severe acute respiratory syndrome (SARS) 3C-like protease (3CL) consists of two distinct folds, namely the N-terminal chymotrypsin fold containing domains I and II, hosting the complete catalytic machinery and the C-terminal extra helical domain III, unique for the coronavirus 3CL proteases [[cite:PUB00094067], [cite:PUB00099877]].</p> <p>The structure of a 3CL, CoV M-pro, has been solved. It is a dimer where each subunit is composed of three domains I, II and III. Domains I and II consist of six-stranded antiparallel β barrels and together resemble the architecture of chymotrypsin and of picornaviruses 3C proteinases. The substrate-binding site is located in a cleft between these two domains. The catalytic site is situated at the centre of the cleft. A long loop connects domain II to the C-terminal domain (domain III). This latter domain, a globular cluster of five helices, has been implicated in the proteolytic activity of M-pro. In the active site of M-pro, Cys and His form a catalytic dyad. In contrast to serine proteinases and other cysteine proteinases, which have a catalytic triad, there is no third catalytic residue present [[cite:PUB00011621], [cite:PUB00022402], [cite:PUB00048878], [cite:PUB00051210]]. Many drugs have been developed to inhibit CoV M-pro [[cite:PUB00094068], [cite:PUB00099876]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Protease Do-like protein; TAIR: AT4G18370.1 DEGP protease 5; Swiss-Prot: sp|Q9SEL7|DEGP5_ARATH Protease Do-like 5, chloroplastic; TrEMBL-Plants: tr|I3SH86|I3SH86_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0359700_LC | 11 | ||
| – | Serine protease; TAIR: AT5G36950.1 DegP protease 10; Swiss-Prot: sp|Q9FIV6|DGP10_ARATH Protease Do-like 10, mitochondrial; TrEMBL-Plants: tr|I1KZS0|I1KZS0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0236200 | 18 | ||
| – | Serine protease; TAIR: AT3G27925.1 DegP protease 1; Swiss-Prot: sp|O22609|DEGP1_ARATH Protease Do-like 1, chloroplastic; TrEMBL-Plants: tr|I3S8D7|I3S8D7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0246100 | 23 | ||
| – | Serine protease; TAIR: AT3G27925.1 DegP protease 1; Swiss-Prot: sp|O22609|DEGP1_ARATH Protease Do-like 1, chloroplastic; TrEMBL-Plants: tr|I3S8D7|I3S8D7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0246100 | 23 | ||
| – | Serine protease; TAIR: AT5G39830.1 Trypsin family protein with PDZ domain-containing protein; Swiss-Prot: sp|Q9LU10|DEGP8_ARATH Protease Do-like 8, chloroplastic; TrEMBL-Plants: tr|I3S3D5|I3S3D5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0259100 | 17 | ||
| – | Serine protease; TAIR: AT5G39830.1 Trypsin family protein with PDZ domain-containing protein; Swiss-Prot: sp|Q9LU10|DEGP8_ARATH Protease Do-like 8, chloroplastic; TrEMBL-Plants: tr|I3S3D5|I3S3D5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0259100 | 23 | ||
| – | DegP protease-like protein; TAIR: AT3G03380.1 DegP protease 7; Swiss-Prot: sp|Q8RY22|DEGP7_ARATH Protease Do-like 7; TrEMBL-Plants: tr|I1LME4|I1LME4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0060100 | 20 | ||
| – | DegP protease-like protein; TAIR: AT3G03380.1 DegP protease 7; Swiss-Prot: sp|Q8RY22|DEGP7_ARATH Protease Do-like 7; TrEMBL-Plants: tr|I1LME4|I1LME4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0060100 | 20 | ||
| – | Protease Do-like protein; TAIR: AT4G18370.1 DEGP protease 5; Swiss-Prot: sp|Q9SEL7|DEGP5_ARATH Protease Do-like 5, chloroplastic; TrEMBL-Plants: tr|I3SH86|I3SH86_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0272800_LC | 11 | ||
| – | Protease Do-like protein; TAIR: AT4G18370.1 DEGP protease 5; Swiss-Prot: sp|Q9SEL7|DEGP5_ARATH Protease Do-like 5, chloroplastic; TrEMBL-Plants: tr|I3SH86|I3SH86_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0272800_LC | 12 | ||
| – | Protease Do-like protein; TAIR: AT4G18370.1 DEGP protease 5; Swiss-Prot: sp|Q9SEL7|DEGP5_ARATH Protease Do-like 5, chloroplastic; TrEMBL-Plants: tr|I3SH86|I3SH86_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0272800_LC | 12 | ||
| – | Protease do-like chloroplastic-like; TAIR: AT4G18370.1 DEGP protease 5; Swiss-Prot: sp|Q9SEL7|DEGP5_ARATH Protease Do-like 5, chloroplastic; TrEMBL-Plants: tr|I3SH86|I3SH86_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0272800_LC | 6 | ||
| – | Serine protease; TAIR: AT4G18370.1 DEGP protease 5; Swiss-Prot: sp|Q9SEL7|DEGP5_ARATH Protease Do-like 5, chloroplastic; TrEMBL-Plants: tr|I3SH86|I3SH86_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0311000 | 10 | ||
| – | Glyoxysomal processing protease, glyoxysomal-like protein; TAIR: AT1G28320.1 protease-like protein; Swiss-Prot: sp|Q8VZD4|DEG15_ARATH Glyoxysomal processing protease, glyoxysomal; TrEMBL-Plants: tr|G7ISD6|G7ISD6_MEDTR Glyoxysomal processing protease, glyoxysomal-like protein; Found in the gene: LotjaGi6g1v0329800 | 8 | ||
| – | Protease Do-like protein; TAIR: AT4G18370.1 DEGP protease 5; Swiss-Prot: sp|Q9SEL7|DEGP5_ARATH Protease Do-like 5, chloroplastic; TrEMBL-Plants: tr|I3SH86|I3SH86_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0340800_LC | 7 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF50494 | SUPERFAMILY | 1 | 6.67 |