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IPR039356

Source: InterPro

Description

IPR039356 is a 5'-deoxynucleotidase YfbR/HDDC2.

<p>Escherichia coli YfbR is a conserved HD-domain-containing protein with orthologues found in bacteria, archaea, and eukaryotes. YfbR shows strict specificity towards deoxyribonucleoside 5'-monophosphates [[cite:PUB00034504], [cite:PUB00048646]], and has been established as an essential component of the deoxycytidine pathway for de novo synthesis of thymidylate [[cite:PUB00053957]]. The human genome encodes one YfbR orthologue, the uncharacterized HD-domain-containing protein HDDC2. In yeast, HD-domain proteins YGK1 (YGL101W) and YB92 (YBR242W) from Saccharomyces cerevisiae are nucleoside 5'-monophosphatases, with substrate preference for deoxyribonucleoside 5'-monophosphatase over ribonucleoside 5'-monophosphatase [[cite:PUB00089491]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0002953
Molecular function 5'-deoxynucleotidase activity Catalysis of the reaction:a 2'-deoxyribonucleoside 5'-monophosphate + H20=a 2'-deoxyribonucleoside + phosphate.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
LotjaGi2g1v0285000.1
– HD domain-containing protein 2; TAIR: AT1G26160.1 Metal-dependent phosphohydrolase; Swiss-Prot: sp|P87242|YC0H_SCHPO HD domain-containing protein C4G3.17; TrEMBL-Plants: tr|I3SNE6|I3SNE6_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0285000
Domains
10
LotjaGi6g1v0198900.1
– HD domain-containing protein 2; TAIR: AT2G23820.2 Metal-dependent phosphohydrolase; Swiss-Prot: sp|Q1LUI2|HDDC2_DANRE HD domain-containing protein 2; TrEMBL-Plants: tr|I1JGU2|I1JGU2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0198900
Domains
17

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 50.00