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IPR039357 is a 3-oxo-5-alpha-steroid 4-dehydrogenase/very-long-chain enoyl-CoA reductase.
<p>3-oxo-5-alpha-steroid 4-dehydrogenases ([ec:1.3.99.5]) catalyse the conversion of 3-oxo-5-alpha-steroid + acceptor to 3-oxo-delta(4)-steroid + reduced acceptor. The steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during foetal development [[cite:PUB00007121]]. In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally. A related steroid reductase enzyme, DET2, is found in plants such as Arabidopsis. Mutations in this enzyme cause defects in light-regulated development [[cite:PUB00007122]].</p> <p>Another enzyme in this entry is very-long-chain enoyl-CoA reductase (TECR; [ec:1.3.1.93]), which catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle by reducing the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation [[cite:PUB00089496]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Steroid 5-alpha reductase; TAIR: AT3G55360.1 3-oxo-5-alpha-steroid 4-dehydrogenase family protein; Swiss-Prot: sp|Q9M2U2|TECR_ARATH Very-long-chain enoyl-CoA reductase; TrEMBL-Plants: tr|B7FIH8|B7FIH8_MEDTR Trans-2-enoyl-CoA reductase; Found in the gene: LotjaGi1g1v0058000 | 14 | ||
| – | Steroid 5-alpha reductase; TAIR: AT3G55360.1 3-oxo-5-alpha-steroid 4-dehydrogenase family protein; Swiss-Prot: sp|Q9M2U2|TECR_ARATH Very-long-chain enoyl-CoA reductase; TrEMBL-Plants: tr|B7FIH8|B7FIH8_MEDTR Trans-2-enoyl-CoA reductase; Found in the gene: LotjaGi1g1v0058000 | 14 | ||
| – | 3-oxo-5-alpha-steroid 4-dehydrogenase; TAIR: AT2G38050.1 3-oxo-5-alpha-steroid 4-dehydrogenase family protein; Swiss-Prot: sp|Q2QDF6|DET2_GOSHI Steroid 5-alpha-reductase DET2; TrEMBL-Plants: tr|A0A1J7GLA8|A0A1J7GLA8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0572300 | 13 | ||
| – | 3-oxo-5-alpha-steroid 4-dehydrogenase; TAIR: AT2G38050.1 3-oxo-5-alpha-steroid 4-dehydrogenase family protein; Swiss-Prot: sp|Q2QDF6|DET2_GOSHI Steroid 5-alpha-reductase DET2; TrEMBL-Plants: tr|A0A1J7GLA8|A0A1J7GLA8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0572300 | 13 | ||
| – | 3-oxo-5-alpha-steroid 4-dehydrogenase family protein; TAIR: AT5G16010.1 3-oxo-5-alpha-steroid 4-dehydrogenase family protein; Swiss-Prot: sp|Q2QDF6|DET2_GOSHI Steroid 5-alpha-reductase DET2; TrEMBL-Plants: tr|I1JDE1|I1JDE1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0129600 | 11 | ||
| – | 3-oxo-5-alpha-steroid 4-dehydrogenase family protein; TAIR: AT5G16010.1 3-oxo-5-alpha-steroid 4-dehydrogenase family protein; Swiss-Prot: sp|Q55C17|TECR_DICDI Very-long-chain enoyl-CoA reductase; TrEMBL-Plants: tr|A0A151RMQ6|A0A151RMQ6_CAJCA Trans-2,3-enoyl-CoA reductase; Found in the gene: LotjaGi2g1v0129700 | 11 | ||
| – | 3-oxo-5-alpha-steroid 4-dehydrogenase family protein; TAIR: AT5G16010.1 3-oxo-5-alpha-steroid 4-dehydrogenase family protein; Swiss-Prot: sp|Q55C17|TECR_DICDI Very-long-chain enoyl-CoA reductase; TrEMBL-Plants: tr|A0A151RMQ6|A0A151RMQ6_CAJCA Trans-2,3-enoyl-CoA reductase; Found in the gene: LotjaGi2g1v0129700 | 11 | ||
| – | 3-oxo-5-alpha-steroid 4-dehydrogenase family protein; TAIR: AT5G16010.1 3-oxo-5-alpha-steroid 4-dehydrogenase family protein; Swiss-Prot: sp|Q2QDF6|DET2_GOSHI Steroid 5-alpha-reductase DET2; TrEMBL-Plants: tr|A0A151RMQ6|A0A151RMQ6_CAJCA Trans-2,3-enoyl-CoA reductase; Found in the gene: LotjaGi2g1v0129700 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TRANSMEMBRANE | Phobius | 1 | 12.50 |