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IPR039694 is a WD repeat-containing protein 11.
<p>Members of the WDR11 family share a domain architecture consisting of two β-propellers followed by a TPR domain. WDR11 has been implicated in human developmental genetic disorders characterised by delayed puberty and infertility. WDR11 modulates the Hedgehog (Hh) signalling pathway and is essential for adequate ciliogenesis [[cite:PUB00089991]]. The β-propellers in WDR11 are involved in protein-protein interaction. This are essential for proper interaction with EMX1, a homeodomain transcription factor involved in the development of olfactory neurons. Impaired pubertal development is suggested to result from a deficiency of productive WDR11 protein interaction [[cite:PUB00155546]]. WDR11 is also involved in vesicle traffic as it binds TBC1D23, a vesicle-golgin adaptor required for endosome-to-Golgi trafficking [[cite:PUB00090056]]. WDR11 is part of the WDR11 complex (consisting of WDR11, C17orf75 and FAM91A) that facilitates the tethering of AP-1-derived vesicles [[cite:PUB00089990]]. Mutations of the WDR11 gene have been linked to congenital hypogonadotropic hypogonadism (CHH) and Kallmann syndrome (KS), human developmental genetic disorders defined by delayed puberty and infertility [[cite:PUB00089991]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Transducin family protein/WD-40 repeat protein; TAIR: AT3G33530.1 Transducin family protein / WD-40 repeat family protein; Swiss-Prot: sp|Q9BZH6|WDR11_HUMAN WD repeat-containing protein 11; TrEMBL-Plants: tr|I1LZP4|I1LZP4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0273500 | 10 | ||
| – | Transducin family protein/WD-40 repeat protein; TAIR: AT3G33530.1 Transducin family protein / WD-40 repeat family protein; Swiss-Prot: sp|Q9BZH6|WDR11_HUMAN WD repeat-containing protein 11; TrEMBL-Plants: tr|I1LZP4|I1LZP4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0273500 | 10 | ||
| – | Transducin family protein/WD-40 repeat protein; TAIR: AT3G33530.1 Transducin family protein / WD-40 repeat family protein; Swiss-Prot: sp|Q9BZH6|WDR11_HUMAN WD repeat-containing protein 11; TrEMBL-Plants: tr|I1LZP4|I1LZP4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0273500 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 33.33 |