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IPR039753 is a mRNA cap guanine-N7 methyltransferase.
<p>This entry represents mRNA (guanine-N(7))-methyltransferase, which can either be found as a single domain protein, or as a domain within the mRNA-capping enzyme catalytic subunit.</p> <p>mRNA (guanine-N(7))-methyltransferase methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. It binds RNA containing 5'-terminal GpppC [[cite:PUB00058114], [cite:PUB00027904], [cite:PUB00058116], [cite:PUB00058117], [cite:PUB00058115], [cite:PUB00058118], [cite:PUB00100699]]. Viral mRNA capping enzymes, meanwhile, are multidomain proteins that catalyse the first two reactions in the mRNA cap formation pathway [[cite:PUB00100699]]. They are heterodimers consisting of a large (catalytic) and small subunit.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | MRNA (guanine-N7-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | MRNA cap guanine-N7 methyltransferase; TAIR: AT3G52210.3 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein; Swiss-Prot: sp|Q5HZ60|MCES2_ARATH mRNA cap guanine-N7 methyltransferase 2; TrEMBL-Plants: tr|V7ASJ5|V7ASJ5_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0283100 | 10 | ||
| – | MRNA cap guanine-N7 methyltransferase; TAIR: AT3G20650.1 mRNA capping enzyme family protein; Swiss-Prot: sp|Q9LHQ7|MCES1_ARATH mRNA cap guanine-N7 methyltransferase 1; TrEMBL-Plants: tr|A0A151RKT4|A0A151RKT4_CAJCA mRNA cap guanine-N7 methyltransferase; Found in the gene: LotjaGi1g1v0339600 | 13 | ||
| – | MRNA cap guanine-N7 methyltransferase; TAIR: AT3G20650.1 mRNA capping enzyme family protein; Swiss-Prot: sp|Q9LHQ7|MCES1_ARATH mRNA cap guanine-N7 methyltransferase 1; TrEMBL-Plants: tr|A0A151RKT4|A0A151RKT4_CAJCA mRNA cap guanine-N7 methyltransferase; Found in the gene: LotjaGi1g1v0339600 | 13 | ||
| – | MRNA cap guanine-N7 methyltransferase; TAIR: AT3G20650.1 mRNA capping enzyme family protein; Swiss-Prot: sp|Q9LHQ7|MCES1_ARATH mRNA cap guanine-N7 methyltransferase 1; TrEMBL-Plants: tr|A0A151RKT4|A0A151RKT4_CAJCA mRNA cap guanine-N7 methyltransferase; Found in the gene: LotjaGi1g1v0339600 | 13 | ||
| – | MRNA cap guanine-N7 methyltransferase; TAIR: AT3G20650.1 mRNA capping enzyme family protein; Swiss-Prot: sp|Q9LHQ7|MCES1_ARATH mRNA cap guanine-N7 methyltransferase 1; TrEMBL-Plants: tr|K7L7W0|K7L7W0_SOYBN mRNA cap guanine-N7 methyltransferase; Found in the gene: LotjaGi3g1v0095400 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 20.00 |