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IPR039800

Source: InterPro

Description

IPR039800 is a Calcium uptake protein 1/2/3.

<p>This entry represents a group of calcium uptake proteins, including MICU1/2/3 from humans. They contain the conserved EF-hand Ca2+-binding domains. MICU1 and MICU2 are the main regulators of the mitochondrial Ca(2+)-uniporter (MCU) [[cite:PUB00090117]]. MICU2 forms a heterodimer with MICU1 to modulate MCU channel activity [[cite:PUB00090119]]. MICU3 a tissue-specific enhancer of mitochondrial calcium uptake [[cite:PUB00090118]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0005509
Molecular function Calcium ion binding Interacting selectively and non-covalently with calcium ions (Ca2+).
Subterm of
GO:0006851
Biological process Mitochondrial calcium ion transmembrane transport The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion.
Subterm of

Associated Lotus transcripts 7

Transcript Name Description Predicted domains Domain count
LotjaGi4g1v0280800.1
– Calcium uptake protein 1; TAIR: AT4G32060.1 calcium-binding EF hand family protein; Swiss-Prot: sp|Q9SZ45|MICU_ARATH Calcium uptake protein, mitochondrial; TrEMBL-Plants: tr|K7M068|K7M068_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0280800
Domains
17
LotjaGi4g1v0280800.2
– Calcium uptake protein 1; TAIR: AT4G32060.1 calcium-binding EF hand family protein; Swiss-Prot: sp|Q9SZ45|MICU_ARATH Calcium uptake protein, mitochondrial; TrEMBL-Plants: tr|K7M068|K7M068_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0280800
Domains
19
LotjaGi5g1v0058000.1
– Calcium uptake protein 1; TAIR: AT4G32060.1 calcium-binding EF hand family protein; Swiss-Prot: sp|Q9SZ45|MICU_ARATH Calcium uptake protein, mitochondrial; TrEMBL-Plants: tr|A0A072VEI6|A0A072VEI6_MEDTR Calcium-binding EF hand protein; Found in the gene: LotjaGi5g1v0058000
Domains
15
LotjaGi5g1v0058000.2
– Calcium uptake protein 1; TAIR: AT4G32060.1 calcium-binding EF hand family protein; Swiss-Prot: sp|Q9SZ45|MICU_ARATH Calcium uptake protein, mitochondrial; TrEMBL-Plants: tr|A0A072VEI6|A0A072VEI6_MEDTR Calcium-binding EF hand protein; Found in the gene: LotjaGi5g1v0058000
Domains
15
LotjaGi5g1v0299600_LC.1
– Calcium uptake protein 1; TAIR: AT4G32060.1 calcium-binding EF hand family protein; Swiss-Prot: sp|Q9SZ45|MICU_ARATH Calcium uptake protein, mitochondrial; TrEMBL-Plants: tr|I3S126|I3S126_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0299600_LC
Domains
3
LotjaGi5g1v0299600_LC.2
– Calcium uptake protein 1; TAIR: AT4G32060.1 calcium-binding EF hand family protein; Swiss-Prot: sp|Q9SZ45|MICU_ARATH Calcium uptake protein, mitochondrial; TrEMBL-Plants: tr|I3S126|I3S126_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0299600_LC
Domains
3
LotjaGi5g1v0299600_LC.3
– Calcium uptake protein 1; TAIR: AT4G32060.1 calcium-binding EF hand family protein; Swiss-Prot: sp|Q9SZ45|MICU_ARATH Calcium uptake protein, mitochondrial; TrEMBL-Plants: tr|I3S126|I3S126_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0299600_LC
Domains
3

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
PTHR12294:SF23 PANTHER 1 14.29