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IPR039852 is a Cullin-associated NEDD8-dissociated protein 1/2.
<p>This entry includes cullin-associated NEDD8-dissociated proteins 1 (CAND1 also known as TIP120A) and 2 (CAND2); these proteins have a C-terminal TATA-binding protein interacting (TIP20) domain. CAND1 is required for the assembly of the SCF E3 ubiquitin ligase complex. The SCF ubiquitin E3 ligase consists of SKP1, CUL1 and F-box protein, and it regulates ubiquitin-dependent proteolysis. CAND1 binds to CUL1, preventing it from associating with the other components that form the ligase. Neddylation of CUL1 (or the presence of SKP1 and ATP) dissociates it from CAND1, allowing the ligase complex to form [[cite:PUB00090221], [cite:PUB00090222], [cite:PUB00090223]]. CAND1 also interacts with CUL3, a component of the Cul3-dependent E3 ubiquitin ligase complex [[cite:PUB00090224]]. CAND1 has been proposed to be an F-box protein exchange factor, and as substrates of the ligase complex are degraded by the proteasome and depleted, the ligase complex enters an intermediate, deneddylated state when CAND1 can bind, promoting dissociation of the substrate-recognition subunit and recruitment of a new substrate-recognition subunit [[cite:PUB00090225]]. CAND2 is uncharacterized but is assumed to have similar roles to CAND1.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | SCF complex assembly | The aggregation, arrangement and bonding together of a set of components to form the SKP1-Cullin/Cdc53-F-box protein ubiquitin ligase (SCF) complex. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Cullin-associated NEDD8-dissociated protein 1; TAIR: AT2G02560.2 cullin-associated and neddylation dissociated; Swiss-Prot: sp|Q8L5Y6|CAND1_ARATH Cullin-associated NEDD8-dissociated protein 1; TrEMBL-Plants: tr|I1MQT7|I1MQT7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0001800 | 8 | ||
| – | Cullin-associated NEDD8-dissociated protein 1; TAIR: AT2G02560.2 cullin-associated and neddylation dissociated; Swiss-Prot: sp|Q8L5Y6|CAND1_ARATH Cullin-associated NEDD8-dissociated protein 1; TrEMBL-Plants: tr|I1MQT7|I1MQT7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0001800 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 50.00 |