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IPR039894 is a tRNA pseudouridine synthase Pus10-like.
<p>Archaeal Pus10 is responsible for the synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs [[cite:PUB00056793]]. This entry also includes Pus10 homologues from eukaryotes. Human Pus10 homologue is a modulator of TRAIL-induced cell death and is required for the progression of the apoptotic signal through intrinsic mitochondrial cell death [[cite:PUB00090267], [cite:PUB00090268]]. Although eukaryotic Pus10 shares a conserved catalytic domain with archaeal Pus10 genes, their biological roles are not resolved [[cite:PUB00090269]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | TRNA pseudouridine synthase Pus10, putative; TAIR: AT1G20410.1 Pseudouridine synthase family protein; Swiss-Prot: sp|Q3MIT2|PUS10_HUMAN Putative tRNA pseudouridine synthase Pus10; TrEMBL-Plants: tr|A0A151TFB1|A0A151TFB1_CAJCA Putative tRNA pseudouridine synthase Pus10; Found in the gene: LotjaGi5g1v0001600 | 7 | ||
| – | TRNA pseudouridine synthase Pus10, putative; TAIR: AT1G20410.1 Pseudouridine synthase family protein; Swiss-Prot: sp|Q3MIT2|PUS10_HUMAN Putative tRNA pseudouridine synthase Pus10; TrEMBL-Plants: tr|A0A151TFB1|A0A151TFB1_CAJCA Putative tRNA pseudouridine synthase Pus10; Found in the gene: LotjaGi5g1v0001600 | 7 | ||
| – | TRNA pseudouridine synthase Pus10, putative; TAIR: AT1G20410.1 Pseudouridine synthase family protein; Swiss-Prot: sp|Q3MIT2|PUS10_HUMAN Putative tRNA pseudouridine synthase Pus10; TrEMBL-Plants: tr|A0A151TFB1|A0A151TFB1_CAJCA Putative tRNA pseudouridine synthase Pus10; Found in the gene: LotjaGi5g1v0001600 | 7 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF55120 | SUPERFAMILY | 1 | 33.33 |