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IPR040177

Source: InterPro

Description

IPR040177 is a Proton-coupled zinc antiporter SLC30A9.

<p>This entry includes proton-coupled zinc ion antiporters which mediate the export of zinc from the mitochondria, being involved in intracellular zinc homeostasis, zinc mobilization as well as mitochondrial morphology and health [[cite:PUB00090661], [cite:PUB00103573], [cite:PUB00103574], [cite:PUB00103575]]. A mutation in the human gene leads to an autosomal recessive cerebro-renal syndrome associated with early-onset neurological deterioration, severe intellectual disability, profound ataxia, camptocormia and oculomotor apraxia [[cite:PUB00090661]]. An uncharacterized homologue from Arabidopsis thaliana is known as metal tolerance protein C4 (MTPC4).</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0008324
Molecular function Cation transmembrane transporter activity Enables the transfer of cation from one side of a membrane to the other.
Subterm of

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
LotjaGi3g1v0345200.1
– Metal tolerance protein C4; TAIR: AT1G51610.1 Cation efflux family protein; Swiss-Prot: sp|Q8H1G3|MTPC4_ARATH Metal tolerance protein C4; TrEMBL-Plants: tr|C6TAH5|C6TAH5_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi3g1v0345200
Domains
12

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TRANSMEMBRANE Phobius 1 100.00