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IPR040323 is a EARP and GARP complex-interacting protein 1.
<p>Proteins in this entry contain WD40 repeats. This entry includes mammalian EARP and GARP complex-interacting protein 1 (EIPR1 or TSSC1), which is a component of the endosomal retrieval machinery, binding to both the tethering complexes GARP and EARP. GARP participates in SNARE-dependent fusion of endosome-derived carriers with the trans-Golgi network, wheras EARP does the same for recycling endosomes [[cite:PUB00090818]]. Also included in this family is the EARP-interacting protein 1 from the nematode Caenorhabditis elegans, which trafficks cargo to the dense-core vesicle, a secretory organelle that mediates the regulated release of peptide hormones, growth factors, and biogenic amines and which originates from the trans-Golgi of neurons and neuroendocrine cells [[cite:PUB00090819]]. The WD repeat-containing protein DWA2 from Arabidopsis thaliana is also a member of this family. DWA2 is a component of an E3 ubiquitin-protein ligase complex that acts as negative regulator in abscisic acid signaling [[cite:PUB00090820]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Transducin/WD-like repeat-protein; TAIR: AT1G20540.1 Transducin/WD40 repeat-like superfamily protein; Swiss-Prot: sp|Q6NPN9|DWA2_ARATH WD repeat-containing protein DWA2; TrEMBL-Plants: tr|I1JSW6|I1JSW6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0435000 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF50978 | SUPERFAMILY | 1 | 100.00 |