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IPR040366 is a Nuclear polyadenylated RNA-binding protein Nab2/ZC3H14.
<p>Budding yeast Nab2 is a nuclear polyadenylated RNA-binding protein that contains seven CCCH-type zinc fingers and an RGG box [[cite:PUB00090864]]. It is required for nuclear mRNA export and poly(A) tail length control [[cite:PUB00091081], [cite:PUB00091082]]. The tertiary structure has been solved and the protein is all helical ([pdbe:3LCN]). Its animal homologue, known as ZC3H14, has been shown to control poly(A) tail length in neuronal cells [[cite:PUB00091083]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Poly(A) binding | Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA. | ||
| Biological process | Regulation of mRNA stability | Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs. | ||
| Biological process | Negative regulation of mRNA polyadenylation | Any process that stops, prevents or reduces the frequency, rate or extent of mRNA polyadenylation. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | RNA binding family protein, putative; TAIR: AT3G12640.2 RNA binding (RRM/RBD/RNP motifs) family protein; Swiss-Prot: sp|Q9DDY9|PAB2A_XENLA Polyadenylate-binding protein 2-A; TrEMBL-Plants: tr|A0A1J7IG07|A0A1J7IG07_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0059800 | 15 | ||
| – | RNA binding family protein, putative; TAIR: AT3G12640.2 RNA binding (RRM/RBD/RNP motifs) family protein; Swiss-Prot: sp|A6NDY0|EPAB2_HUMAN Embryonic polyadenylate-binding protein 2; TrEMBL-Plants: tr|A0A1J7IG07|A0A1J7IG07_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0124000 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 50.00 |