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IPR002483 is a PWI domain.
<p>The PWI domain, named after a highly conserved PWI tri-peptide located within its N-terminal region, is a ~80 amino acid module, which is found either at the N terminus or at the C terminus of eukaryotic proteins involved in pre-mRNA processing [[cite:PUB00005490]]. It is generally found in association with other domains such as RRM and RS. The PWI domain is a RNA/DNA-binding domain that has an equal preference for single- and double-stranded nucleic acids and is likely to have multiple important functions in pre-mRNA processing [[cite:PUB00019777]]. Proteins containing this domain include the SR-related nuclear matrix protein of 160kDa (SRm160) splicing and 3'-end cleavage-stimulatory factor, and the mammalian splicing factor PRP3. This domain is also present in Rmn1 from S.pombe, a component of a MTREC submodule, which promotes degradation of meiotic mRNAs and regulatory ncRNAs, and is the major nuclear exosome targeting complex for cryptic unstable transcripts (CUTs) and unspliced pre-mRNAs [[cite:PUB00153346]]. Rmn1 homologues from human RBM26/27 may be involved in turnover of nuclear polyadenylated RNA and are important for PAXT-mediated nuclear RNA decay [[cite:PUB00153347]].</p> <p>The PWI domain is a soluble, globular and independently folded domain which consists of a four-helix bundle, with structured N- and C-terminal elements [[cite:PUB00019777]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | MRNA processing | Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Polyadenylate-binding protein 2-A [Medicago truncatula] gi|357457685|ref|XP_003599123.1| | 12 | ||
| – | RNA-binding protein 25; TAIR: AT1G60200.2 splicing factor PWI domain-containing protein / RNA recognition motif (RRM)-containing protein; Swiss-Prot: sp|P49756|RBM25_HUMAN RNA-binding protein 25; TrEMBL-Plants: tr|A0A072UD88|A0A072UD88_MEDTR RNA recognition motif protein, putative; Found in the gene: LotjaGi2g1v0319900 | 20 | ||
| – | RNA-binding protein 25; TAIR: AT1G60200.1 splicing factor PWI domain-containing protein / RNA recognition motif (RRM)-containing protein; Swiss-Prot: sp|P49756|RBM25_HUMAN RNA-binding protein 25; TrEMBL-Plants: tr|G7K1E8|G7K1E8_MEDTR RNA recognition motif protein, putative; Found in the gene: LotjaGi2g1v0319900 | 20 | ||
| – | RNA-binding protein 25; TAIR: AT1G60200.2 splicing factor PWI domain-containing protein / RNA recognition motif (RRM)-containing protein; Swiss-Prot: sp|P49756|RBM25_HUMAN RNA-binding protein 25; TrEMBL-Plants: tr|A0A072UD88|A0A072UD88_MEDTR RNA recognition motif protein, putative; Found in the gene: LotjaGi2g1v0319900 | 20 | ||
| – | RNA-binding protein 25; TAIR: AT1G60200.2 splicing factor PWI domain-containing protein / RNA recognition motif (RRM)-containing protein; Swiss-Prot: sp|P49756|RBM25_HUMAN RNA-binding protein 25; TrEMBL-Plants: tr|A0A072UD88|A0A072UD88_MEDTR RNA recognition motif protein, putative; Found in the gene: LotjaGi2g1v0319900 | 20 | ||
| – | RNA-binding protein 25; TAIR: AT1G60200.1 splicing factor PWI domain-containing protein / RNA recognition motif (RRM)-containing protein; Swiss-Prot: sp|P49756|RBM25_HUMAN RNA-binding protein 25; TrEMBL-Plants: tr|G7K1E8|G7K1E8_MEDTR RNA recognition motif protein, putative; Found in the gene: LotjaGi2g1v0319900 | 20 | ||
| – | RNA binding family protein, putative; TAIR: AT3G12640.2 RNA binding (RRM/RBD/RNP motifs) family protein; Swiss-Prot: sp|Q9DDY9|PAB2A_XENLA Polyadenylate-binding protein 2-A; TrEMBL-Plants: tr|A0A1J7IG07|A0A1J7IG07_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0059800 | 15 | ||
| – | RNA binding family protein, putative; TAIR: AT3G12640.2 RNA binding (RRM/RBD/RNP motifs) family protein; Swiss-Prot: sp|A6NDY0|EPAB2_HUMAN Embryonic polyadenylate-binding protein 2; TrEMBL-Plants: tr|A0A1J7IG07|A0A1J7IG07_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0124000 | 14 | ||
| – | Serine/arginine repetitive matrix protein 1; TAIR: AT2G29210.1 splicing factor PWI domain-containing protein; Swiss-Prot: sp|Q5ZMJ9|SRRM1_CHICK Serine/arginine repetitive matrix protein 1; TrEMBL-Plants: tr|V7AGQ0|V7AGQ0_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0490500 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 11.11 |