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IPR040380 is a HAKAI-like, RING finger, HC subclass.
<p>Hakai is an E3 ubiquitin ligase that disrupts cell-cell contacts in epithelial cells and is upregulated in human colon and gastric adenocarcinomas. It was identified to mediate the posttranslational downregulation of E-cadherin (CDH1), a major component of adherens junctions in epithelial cells and a potent tumour suppressor [[cite:PUB00090884], [cite:PUB00090880], [cite:PUB00090882]]. It also promotes ubiquitination of several other tyrosine-phosphorylated Src substrates, including cortactin (CTTN) and DOK1 [[cite:PUB00090881]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | E3 ubiquitin-protein ligase Hakai; TAIR: AT5G01160.1 RING/U-box superfamily protein; Swiss-Prot: sp|Q5ZHZ4|HAKAI_CHICK E3 ubiquitin-protein ligase Hakai; TrEMBL-Plants: tr|I1N2T3|I1N2T3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0202800 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 100.00 |