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IPR041175 is a VLRF1/Vms1.
<p>This entry represents a domain found in proteins belonging to the VLRF1 clade of the archaeo-eukaryotic RF1 (aeRF1) superfamily. The yeast Vms1 is the founding member the VLRF1 (Vms1-Like Release Factor-1) clade. In addition to the eukaryotic orthologs of Vms1 the VLRF1 clade also contains members from certain bacteria, predominantly bacteroidetes and more divergent versions in certain Archaea [[cite:PUB00091190]].</p> <p>Proteins containing this domain have a conserved glutamine residue in the release factor catalytic loop, suggesting they function as active peptidyl-tRNA hydrolases at the ribosome [[cite:PUB00091190]].</p> <p>This domain is also found in Ankyrin repeat and zinc finger domain-containing protein 1 from humans (ANKZF1), which plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress [[cite:PUB00102007]]. It is an endonuclease that cleaves polypeptidyl-tRNAs downstream of the ribosome-associated quality control (RQC) pathway to release incompletely synthesized polypeptides for degradation [[cite:PUB00151173], [cite:PUB00091190], [cite:PUB00151172]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Ankyrin repeat and zinc finger domain-containing protein 1; TAIR: AT1G01930.1 zinc finger protein-like protein; Swiss-Prot: sp|Q66H85|ANKZ1_RAT Ankyrin repeat and zinc finger domain-containing protein 1; TrEMBL-Plants: tr|I1L6T5|I1L6T5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0463900 | 18 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 100.00 |