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IPR041726 is a Acyl-CoA dehydrogenase family member 10/11, N-terminal.
<p>This entry represents the N-terminal domains of vertebrate ACAD10 and ACAD11, and similar uncharacterized bacterial and eukaryotic proteins. ACADs are a family of flavoproteins that are involved in the beta-oxidation of fatty acyl-CoA derivatives. ACAD deficiency can cause metabolic disorders including muscle fatigue, hypoglycemia, and hepatic lipidosis. There are at least 11 distinct ACADs, some of which show distinct substrate specificities to either straight-chain or branched-chain fatty acids [[cite:PUB00091775]]. ACAD10 is widely expressed in human tissues and highly expressed in liver, kidney, pancreas, and spleen. ACAD10 and ACAD11 are both significantly expressed in human brain tissues [[cite:PUB00091776]]. They contain a long N-terminal domain with similarity to phosphotransferases with a Protein Kinase fold, which is absent in other ACADs. They may exhibit multiple functions in acyl-CoA oxidation pathways. ACAD11 utilizes substrates with carbon chain lengths of 20 to 26, with optimal activity towards C22CoA. ACAD10 may be associated with an increased risk in type II diabetes [[cite:PUB00091777]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Acyl-CoA dehydrogenase; TAIR: AT3G06810.1 acyl-CoA dehydrogenase-like protein; Swiss-Prot: sp|Q8RWZ3|IBR3_ARATH Probable acyl-CoA dehydrogenase IBR3; TrEMBL-Plants: tr|V7AZ54|V7AZ54_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0252100 | 23 | ||
| – | Acyl-CoA dehydrogenase-related family protein; TAIR: AT3G06810.1 acyl-CoA dehydrogenase-like protein; Swiss-Prot: sp|Q8RWZ3|IBR3_ARATH Probable acyl-CoA dehydrogenase IBR3; TrEMBL-Plants: tr|A0A1J7FV79|A0A1J7FV79_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0252100 | 23 | ||
| – | Acyl-CoA dehydrogenase; TAIR: AT3G06810.1 acyl-CoA dehydrogenase-like protein; Swiss-Prot: sp|Q8RWZ3|IBR3_ARATH Probable acyl-CoA dehydrogenase IBR3; TrEMBL-Plants: tr|A0A0R0GAV8|A0A0R0GAV8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0252100 | 25 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd05154 | CDD | 1 | 33.33 |