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IPR041744 is a Bifunctional delta 1-pyrroline-5-carboxylate synthetase, glutamate-5-kinase domain.
<p>This is the glutamate-5-kinase (G5K) domain of the bifunctional delta 1-pyrroline-5-carboxylate synthetase (P5CS), composed of an N-terminal G5K (ProB) and a C-terminal glutamyl 5-phosphate reductase (G5PR, ProA), the first and second enzyme catalyzing proline (and, in mammals, ornithine) biosynthesis. G5K transfers the terminal phosphoryl group of ATP to the γ-carboxyl group of glutamate, and is subject to feedback allosteric inhibition by proline or ornithine. In plants, proline plays an important role as an osmoprotectant and, in mammals, ornithine biosynthesis is crucial for proper ammonia detoxification, since a G5K mutation has been shown to cause human hyperammonaemia [[cite:PUB00091736], [cite:PUB00081170]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Gamma-glutamyl phosphate reductase; TAIR: AT2G39800.1 delta1-pyrroline-5-carboxylate synthase 1; Swiss-Prot: sp|O04015|P5CS_ACTDE Delta-1-pyrroline-5-carboxylate synthase; TrEMBL-Plants: tr|I1JLN5|I1JLN5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0230400 | 34 | ||
| – | Gamma-glutamyl phosphate reductase; TAIR: AT2G39800.1 delta1-pyrroline-5-carboxylate synthase 1; Swiss-Prot: sp|O04226|P5CS_ORYSJ Delta-1-pyrroline-5-carboxylate synthase; TrEMBL-Plants: tr|I1JLN5|I1JLN5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0230400 | 34 | ||
| – | Gamma-glutamyl phosphate reductase; TAIR: AT2G39800.1 delta1-pyrroline-5-carboxylate synthase 1; Swiss-Prot: sp|O04226|P5CS_ORYSJ Delta-1-pyrroline-5-carboxylate synthase; TrEMBL-Plants: tr|I1JLN5|I1JLN5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0230400 | 34 | ||
| – | Gamma-glutamyl phosphate reductase; TAIR: AT3G55610.1 delta 1-pyrroline-5-carboxylate synthase 2; Swiss-Prot: sp|O04226|P5CS_ORYSJ Delta-1-pyrroline-5-carboxylate synthase; TrEMBL-Plants: tr|I1JLN5|I1JLN5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0230400 | 34 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd07079 | CDD | 1 | 25.00 |