Description

IPR041888 is a ZN598/HEL22, RING finger.

<p>This entry represents the RING-HC finger domain in ZNF598 from animals and HEL2 from yeasts [[cite:PUB00092552]].</p> <p>ZNF598 plays a key role in the ribosome quality control (RQC), a pathway that takes place when the ribosome has stalled during translation, leading to degradation of nascent peptide chains. ZNF598 is activated when ribosomes are stalled following translation of prematurely polyadenylated mRNAs [[cite:PUB00092042]]. Independently of its role in RQC, this protein may also act as a negative regulator of interferon-stimulated gene expression [[cite:PUB00155780]]. ZNF598 is associates with eukaryotic initiation factor 4E (eIF4E) homologous protein from mammalian (m4EHP) through binding to Grb10-interacting GYF protein 2 (GIGYF2). The m4EHP-GIGYF2 complex functions as a translational repressor and is essential for normal embryonic development of mammalian [[cite:PUB00092043]].</p> <p>HEL2 in addition to its role in the ribosome quality control, also acts as an activator of the No-Go decay (NGD) pathway by mediating polyubiquitination of monoubiquitinated RPS3/uS3 and RPS7/es7. RPS3/uS3 and RPS7/es7 are first monoubiquitinated by MAG2 and MOT2/NOT4, respectively, and HEL2 mediates formation of 'Lys-63'-linked polyubiquitin chains on monoubiquitin, leading to activation of the NGD pathway in a CUE2-mediated endonucleolytic cleavage [[cite:PUB00160555], [cite:PUB00095791]]. Hel2 is involved ubiquitination and degradation of excess histones [[cite:PUB00073489], [cite:PUB00095791]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 1

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: