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IPR041960 is a Geranylgeranyl transferase type-1 subunit beta.
<p>This entry represents the beta subunit (α6 - α6 barrel fold) of geranylgeranyltransferase type I (GGTase-I)-like proteins containing the protein prenyltransferase (PTase) domain. GGTase-I is a subgroup of the protein prenyltransferase family of lipid-modifying enzymes PTases, which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Prenyltransferases employ a Zn2+ ion to alkylate a thiol group catalyzing the formation of thioether linkages between cysteine residues at or near the C terminus of protein acceptors and the C1 atom of isoprenoid lipids (geranylgeranyl (20-carbon) in the case of GGTase-I) [[cite:PUB00080785]]. GGTase-I prenylates the cysteine in the terminal sequence, 'CAAX' when X is Leu or Phe. Substrates for GTTase-I include the gamma subunit of neural G-proteins and several Ras-related G-proteins [[cite:PUB00080785], [cite:PUB00080792]]. PTases are heterodimeric with both alpha and beta subunits required for catalytic activity.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
GO term | Namespace | Name | Definition | Relationships |
---|---|---|---|---|
Molecular function | Protein geranylgeranyltransferase activity | Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein. | ||
Cellular component | CAAX-protein geranylgeranyltransferase complex | A heterodimeric enzyme, composed of an alpha and a beta subunit. Participates in the post-translational C-terminal modification of several small GTPases, allowing their targeting to the membrane. | ||
Biological process | Protein geranylgeranylation | The covalent attachment of a geranylgeranyl group to a protein. |
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | Geranylgeranyl transferase type-1 subunit beta; TAIR: AT2G39550.1 Prenyltransferase family protein; Swiss-Prot: sp|O80642|PGT1_ARATH Geranylgeranyl transferase type-1 subunit beta; TrEMBL-Plants: tr|I3T2B9|I3T2B9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0538700 | 9 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
cd02895 | CDD | 1 | 100.00 |